PAK4 Protein (AA 1-426) (His-SUMO Tag)
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- 抗原 See all PAK4 蛋白
- PAK4 (P21-Activated Kinase 4 (PAK4))
- 蛋白类型
- Recombinant
- 产品特性
- AA 1-426
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 标记
- This PAK4 protein is labelled with His-SUMO Tag.
- 应用范围
- SDS-PAGE (SDS)
- 序列
- MFGKRKKRVE ISAPSNFEHR VHTGFDQHEQ KFTGLPRQWQ SLIEESARRP KPLVDPACIT SIQPGAPKTI VRGSKGAKDG ALTLLLDEFE NMSVTRSNSL RRDSPPPPAR ARQENGMPEK PPGPRSPQRE PQRVSHEQFR AALQLVVDPG DPRSYLDNFI KIGEGSTGIV CIATVRSSGK LVAVKKMDLR KQQRRELLFN EVVIMRDYQH ENVVEMYNSY LVGDELWVVM EFLEGGALTD IVTHTRMNEE QIAAVCLAVL QALSVLHAQG VIHRDIKSDS ILLTHDGRVK LSDFGFCAQV SKEVPRRKSL VGTPYWMAPE LISRLPYGPE VDIWSLGIMV IEMVDGEPPY FNEPPLKAMK MIRDNLPPRL KNLHKVSPSL KGFLDRLLVR DPAQRATAAE LLKHPFLAKA GPPASIVPLM RQNRTR
- 纯化方法
- SDS-PAGE
- 纯度
- > 90 %
- Top Product
- Discover our top product PAK4 蛋白
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P21-Activated Kinase 4 (PAK4) (AA 1-591) (Active) protein (GST tag)
PAK4 宿主: 人 宿主: Insect cells (Sf21) Recombinant SDS, Func Active
P21-Activated Kinase 4 (PAK4) (AA 300-591) (Active) proteinPAK4 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant SDS, Func Active
P21-Activated Kinase 4 (PAK4) (AA 1-591) (Active) protein (His-GST)PAK4 宿主: 人 宿主: Insect cells (Sf9) Recombinant SDS, Func Active
P21-Activated Kinase 4 (PAK4) (AA 1-259) protein (His tag)PAK4 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
P21-Activated Kinase 4 (PAK4) (AA 68-157) protein (GST tag)PAK4 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
P21-Activated Kinase 4 (PAK4) (AA 1-591) protein (His tag)PAK4 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant SDS
P21-Activated Kinase 4 (PAK4) (AA 1-591) protein (Strep Tag)Crystallography grade PAK4 宿主: 人 宿主: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA
P21-Activated Kinase 4 (PAK4) (AA 1-593) protein (Strep Tag)Crystallography grade PAK4 宿主: 小鼠 宿主: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 0.1-2 mg/mL
- 缓冲液
- 20 mM Tris-HCl based buffer, pH 8.0
- 储存条件
- -80 °C,4 °C,-20 °C
- 储存方法
- Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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- 抗原
- PAK4 (P21-Activated Kinase 4 (PAK4))
- 别名
- PAK4 (PAK4 产品)
- 别名
- 5730488L07Rik Protein, AW555722 Protein, mKIAA1142 Protein, im:5916170 Protein, wu:fd12b01 Protein, zgc:92014 Protein, p21 (RAC1) activated kinase 4 Protein, p21 protein (Cdc42/Rac)-activated kinase 4 Protein, PAK4 Protein, Pak4 Protein, pak4 Protein
- 背景
- Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, growth, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates LIMK1, a kinase that also inhibits the activity of cofilin. Phosphorylates integrin beta5/ITGB5 and thus regulates cell motility. Phosphorylates ARHGEF2 and activates the downstream target RHOA that plays a role in the regulation of assbly of focal adhesions and actin stress fibers. Stimulates cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Alternatively, inhibits apoptosis by preventing caspase-8 binding to death domain receptors in a kinase independent manner. Plays a role in cell-cycle progression by controlling levels of the cell-cycle regulatory protein CDKN1A and by phosphorylating RAN
- 分子量
- 63.9 kDa
- UniProt
- O96013
- 途径
- RTK signaling
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