LCK Protein (AA 1-539, Isoform 3) (His-SUMO Tag)
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- 抗原 See all LCK 蛋白
- LCK (Lymphocyte-Specific Protein tyrosine Kinase (LCK))
- 蛋白类型
- Recombinant
- 产品特性
- Isoform 3, AA 1-539
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 标记
- This LCK protein is labelled with His-SUMO Tag.
- 应用范围
- SDS-PAGE (SDS)
- 序列
- MGCGCSSHPE DDWMENIDVC ENCHYPIVPL DGKGTLLIRN GSEVRDPLVT YEGSNPPASP LQDNLVIALH SYEPSHDGDL GFEKGEQLRI LEQSGEWWKA QSLTTGQEGF IPFNFVAKAN SLEPEPWFFK NLSRKDAERQ LLAPGNTHGS FLIRESESTA GSFSLSVRDF DQNQGEVVKH YKIRNLDNGG FYISPRITFP GLHELVRHYT NASDGLCTRL SRPCQTQKPQ KPWWEDEWEV PRETLKLVER LGAGQFGEVW MGYYNGHTKV AVKSLKQGSM SPDAFLAEAN LMKQLQHQRL VRLYAVVTQE PIYIITEYME NDTLLDSQLE EKGLGASPWG NLGQQLLLLP TGSLVDFLKT PSGIKLTINK LLDMAAQIAE GMAFIEERNY IHRDLRAANI LVSDTLSCKI ADFGLARLIE DNEYTAREGA KFPIKWTAPE AINYGTFTIK SDVWSFGILL TEIVTHGRIP YPGMTNPEVI QNLERGYRMV RPDNCPEELY QLMRLCWKER PEDRPTFDYL RSVLEDFFTA TEGQYQPQP
- 纯化方法
- SDS-PAGE
- 纯度
- > 90 %
- Top Product
- Discover our top product LCK 蛋白
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Lymphocyte-Specific Protein tyrosine Kinase (LCK) (AA 1-509) (Active) protein (His-GST)
LCK 宿主: 人 宿主: Insect cells (Sf9) Recombinant SDS, Func Active
Lymphocyte-Specific Protein tyrosine Kinase (LCK) (AA 1-539) protein (GST tag)LCK 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AP, AA
Lymphocyte-Specific Protein tyrosine Kinase (LCK) (AA 1-100) protein (GST tag)LCK 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AP, AA
Lymphocyte-Specific Protein tyrosine Kinase (LCK) (AA 2-509) protein (His tag)Crystallography grade LCK 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS, Crys
Lymphocyte-Specific Protein tyrosine Kinase (LCK) (AA 2-509) protein (His tag)Crystallography grade LCK 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS, Crys
Lymphocyte-Specific Protein tyrosine Kinase (LCK) (Transcript Variant 2) protein (Myc-DYKDDDDK Tag)LCK 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 0.1-2 mg/mL
- 缓冲液
- 20 mM Tris-HCl based buffer, pH 8.0
- 储存条件
- -80 °C,4 °C,-20 °C
- 储存方法
- Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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- 抗原
- LCK (Lymphocyte-Specific Protein tyrosine Kinase (LCK))
- 别名
- LCK (LCK 产品)
- 别名
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zgc:136695 Protein, LCK Protein, Hck-3 Protein, Lsk Protein, Lskt Protein, p56
Protein, p56Lck Protein, LSK Protein, YT16 Protein, p56lck Protein, pp58lck Protein, P56LCK Protein, tkl Protein, Lck1 Protein, Lcktkr Protein, LCK proto-oncogene, Src family tyrosine kinase Protein, lymphocyte protein tyrosine kinase Protein, lck Protein, LCK Protein, Lck Protein - 背景
- Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells. Plays a key role in T-cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, thereby recruiting the associated LCK protein to the vicinity of the TCR/CD3 complex. LCK then phosphorylates tyrosines residues within the immunoreceptor tyrosine-based activation motifs (ITAM) of the cytoplasmic tails of the TCR-gamma chains and CD3 subunits, initiating the TCR/CD3 signaling pathway. Once stimulated, the TCR recruits the tyrosine kinase ZAP70, that becomes phosphorylated and activated by LCK. Following this, a large number of signaling molecules are recruited, ultimately leading to lymphokine production. LCK also contributes to signaling by other receptor molecules. Associates directly with the cytoplasmic tail of CD2, which leads to hyperphosphorylation and activation of LCK. Also plays a role in the IL2 receptor-linked signaling pathway that controls the T-cell proliferative response. Binding of IL2 to its receptor results in increased activity of LCK. Is expressed at all stages of thymocyte development and is required for the regulation of maturation events that are governed by both pre-TCR and mature alpha beta TCR. Phosphorylates other substrates including RUNX3, PTK2B/PYK2, the microtubule-associated protein MAPT, RHOH or TYROBP
- 分子量
- 77.2 kDa
- UniProt
- P06239
- 途径
- TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Transition Metal Ion Homeostasis, Positive Regulation of Endopeptidase Activity, CXCR4-mediated Signaling Events, Thromboxane A2 Receptor Signaling
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