LCK 产品
(Lymphocyte-Specific Protein tyrosine Kinase (LCK))
Categories
This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants, encoding the same protein, have been described. [provided by RefSeq, Jul 2008].
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Featured LCK Categories
LCK 抗体
High quality antibodies with extensive validation data.
LCK ELISA试剂盒
Reliable ELISA kits for a wide range of species.
LCK 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended LCK 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IP, RNAi
Validations
- (6)
Cat. No.
ABIN561649
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC
Validations
- (6)
Cat. No.
ABIN3023130
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, FACS, IP, ICC
Validations
- (7)
- (4)
Cat. No.
ABIN94422
Quantity
0.1 mg
Datasheet
Datasheet
Recommended LCK ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Chicken
Analytical Method
Validations
Cat. No.
ABIN1153011
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Semi-Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN4886174
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Analytical Method
Qualitative Cell ELISA
Validations
Cat. No.
ABIN1380629
Quantity
2 x 96 tests
Datasheet
Datasheet
Recommended LCK 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Insect cells (Sf9)
Validations
- (2)
Cat. No.
ABIN5570565
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1309224
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1309226
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our LCK Products
: "Single-cell-level protein analysis revealing the roles of autoantigen-reactive B lymphocytes in autoimmune disease and the murine model." in: eLife, Vol. 10, (2021) (PubMed).: "Regulation of Src family kinases involved in T cell receptor signaling by protein-tyrosine phosphatase CD148." in: The Journal of biological chemistry, Vol. 286, Issue 25, pp. 22101-12, (2011) (PubMed).
: "PRR7 is a transmembrane adaptor protein expressed in activated T cells involved in regulation of T cell receptor signaling and apoptosis." in: The Journal of biological chemistry, Vol. 286, Issue 22, pp. 19617-29, (2011) (PubMed).
: "Tyrosine phosphorylation by Src within the cavity of the adenine nucleotide translocase 1 regulates ADP/ATP exchange in mitochondria." in: American journal of physiology. Cell physiology, Vol. 298, Issue 3, pp. C740-8, (2010) (PubMed).
: "The effects of membrane compartmentalization of Csk on TCR signaling." in: Biochimica et biophysica acta, (2010) (PubMed).
: "Specific and nonspecific B-cell function in the small intestines of patients with Whipple's disease." in: Infection and immunity, Vol. 78, Issue 11, pp. 4589-92, (2010) (PubMed).
: "Protein tyrosine kinase p56lck-deficiency confers hypersusceptibility to rho-fluorophenylalanine (pFPhe)-induced apoptosis by augmenting mitochondrial apoptotic pathway in human Jurkat T cells." in: Biochemical and biophysical research communications, Vol. 377, Issue 1, pp. 280-5, (2008) (PubMed).
: "Suppression of proximal T cell receptor signaling and lytic function in CD8+ tumor-infiltrating T cells." in: Cancer research, Vol. 67, Issue 23, pp. 11447-54, (2007) (PubMed).
: "Dendritic cells sensitize TCRs through self-MHC-mediated Src family kinase activation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 178, Issue 4, pp. 2262-71, (2007) (PubMed).
: "A constitutively active Lck kinase promotes cell proliferation and resistance to apoptosis through signal transducer and activator of transcription 5b activation." in: Molecular cancer research : MCR, Vol. 4, Issue 1, pp. 39-45, (2006) (PubMed).
Synonyms and alternative names related to LCK
LCK proto-oncogene, Src family tyrosine kinase (lck), LCK proto-oncogene, Src family tyrosine kinase (LCK), lymphocyte protein tyrosine kinase (Lck), LCK proto-oncogene, Src family tyrosine kinase (Lck), Hck-3, LCK, Lck1, Lcktkr, Lsk, LSK, Lskt, p56Protein level used designations for LCK
- lymphocyte protein tyrosine kinase
- lymphocyte-specific protein tyrosine kinase
- tyrosine-protein kinase Lck-like
- leukocyte C-terminal Src kinase
- lymphocyte cell-specific protein-tyrosine kinase
- proto-oncogene tyrosine-protein kinase LCK
- T-lymphocyte specific protein tyrosine kinase p56lck
- p56(LSTRA) protein-tyrosine kinase
- t cell-specific protein-tyrosine kinase
- tyrosine-protein kinase Lck
- tyrosine protein kinase
- tyrosine-protein kinase LCK
- p56-LCK
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