Ephrin A1 Protein (EFNA1) (AA 19-182) (His-SUMO Tag)
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- 抗原 See all Ephrin A1 (EFNA1) 蛋白
- Ephrin A1 (EFNA1)
- 蛋白类型
- Recombinant
- 产品特性
- AA 19-182
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 标记
- This Ephrin A1 protein is labelled with His-SUMO Tag.
- 应用范围
- SDS-PAGE (SDS)
- 序列
- DRHTVFWNSS NPKFRNEDYT IHVQLNDYVD IICPHYEDHS VADAAMEQYI LYLVEHEEYQ LCQPQSKDQV RWQCNRPSAK HGPEKLSEKF QRFTPFTLGK EFKEGHSYYY ISKPIHQHED RCLRLKVTVS GKITHSPQAH VNPQEKRLAA DDPEVRVLHS IAHS
- 纯化方法
- SDS-PAGE
- 纯度
- > 90 %
- Top Product
- Discover our top product EFNA1 蛋白
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Ephrin A1 (EFNA1) (Active) protein (His tag,Fc Tag)
EFNA1 宿主: 小鼠 宿主: 人细胞 Recombinant > 90 % as determined by SDS-PAGE Active
Ephrin A1 (EFNA1) (AA 1-205) protein (GST tag)EFNA1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Ephrin A1 (EFNA1) (AA 21-130) protein (GST tag)EFNA1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Ephrin A1 (EFNA1) (AA 18-182), (full length) protein (His tag)EFNA1 宿主: 大鼠 宿主: 酵母菌 Recombinant > 90 % ELISA
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 0.1-2 mg/mL
- 缓冲液
- 20 mM Tris-HCl based buffer, pH 8.0
- 储存条件
- -80 °C,4 °C,-20 °C
- 储存方法
- Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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- 抗原
- Ephrin A1 (EFNA1)
- 别名
- EFNA1 (EFNA1 产品)
- 别名
- Xefrin-A1 Protein, b61 Protein, ecklg Protein, efl1 Protein, efna1 Protein, efna1a Protein, elfa-a Protein, epha1 Protein, eplg1 Protein, lerk1 Protein, tnfaip4 Protein, xelf-a' Protein, xelfa Protein, AI325262 Protein, B61 Protein, Efl1 Protein, Epl1 Protein, Eplg1 Protein, Lerk1 Protein, ECKLG Protein, EFL1 Protein, EPLG1 Protein, LERK-1 Protein, LERK1 Protein, TNFAIP4 Protein, efna1b Protein, MGC130661 Protein, ephrin-A1 S homeolog Protein, ephrin-A1 Protein, ephrin A1 Protein, ephrin-A1b Protein, ephrin-A1 L homeolog Protein, efna1.S Protein, efna1 Protein, EFNA1 Protein, efna1b Protein, Efna1 Protein, efna1.L Protein
- 背景
- Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assbly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of bryonic neuronal growth cone and regulates dendritic spine morphogenesis.
- 分子量
- 35.34 kDa
- UniProt
- P20827
- 途径
- RTK signaling
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