CETN2 Protein (AA 1-172, full length) (His-SUMO Tag)
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- 抗原 See all CETN2 蛋白
- CETN2 (Centrin, EF-Hand Protein, 2 (CETN2))
- 蛋白类型
- Recombinant
- 产品特性
- AA 1-172, full length
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 标记
- This CETN2 protein is labelled with His-SUMO Tag.
- 应用范围
- SDS-PAGE (SDS)
- 序列
- MASNFKKANM ASSSQRKRMS PKPELTEEQK QEIREAFDLF DADGTGTIDV KELKVAMRAL GFEPKKEEIK KMISEIDKEG TGKMNFGDFL TVMTQKMSEK DTKEEILKAF KLFDDDETGK ISFKNLKRVA KELGENLTDE ELQEMIDEAD RDGDGEVSEQ EFLRIMKKTS LY
- 纯化方法
- SDS-PAGE
- 纯度
- > 90 %
- Top Product
- Discover our top product CETN2 蛋白
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Centrin, EF-Hand Protein, 2 (CETN2) (AA 1-172) protein (His tag)
CETN2 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Centrin, EF-Hand Protein, 2 (CETN2) (AA 1-172) protein (GST tag)CETN2 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Centrin, EF-Hand Protein, 2 (CETN2) (AA 85-172) protein (GST tag)CETN2 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Centrin, EF-Hand Protein, 2 (CETN2) (AA 2-172) protein (His tag)Crystallography grade CETN2 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Centrin, EF-Hand Protein, 2 (CETN2) (AA 2-172) protein (His tag)Crystallography grade CETN2 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 0.1-2 mg/mL
- 缓冲液
- 20 mM Tris-HCl based buffer, pH 8.0
- 储存条件
- -80 °C,4 °C,-20 °C
- 储存方法
- Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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- 抗原
- CETN2 (Centrin, EF-Hand Protein, 2 (CETN2))
- 别名
- CETN2 (CETN2 产品)
- 别名
- cb732 Protein, CETN2 Protein, 1110034A02Rik Protein, AI326150 Protein, Calt Protein, caltractin Protein, CALT Protein, CEN2 Protein, caltractin Protein, centrin 2 Protein, centrin 4 Protein, LOC412449 Protein, CETN2 Protein, cetn4 Protein, Cetn2 Protein
- 背景
- Plays a fundamental role in microtubule organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CCP110.Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with RAD23B appears to stabilize XPC. In vitro, stimulates DNA binding of the XPC:RAD23B dimer.The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair.Component of the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, DSS1, and either centrin CETN2 or CETN3 . The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery .
- 分子量
- 35.7 kDa
- UniProt
- P41208
- 途径
- DNA Damage Repair, M Phase
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