AIMP1
宿主: 人
宿主: 大肠杆菌(E. Coli)
Recombinant
>95 % as determined by SDS-PAGE
Func
Active
应用备注
This recombinant protein can be used for WB.
限制
仅限研究用
状态
Lyophilized
缓冲液
PBS, pH 7.4
注意事项
Avoid repeated freeze-thaw cycles.
储存条件
-20 °C,-80 °C
储存方法
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C.
抗原
AIMP1
(Aminoacyl tRNA Synthetase Complex-Interacting Multifunctional Protein 1 (AIMP1))
Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 (AIMP1) is also known as multisynthase complex auxiliary component p43 and endothelial monocyte-activating polypeptide II (EMAP-II). AIMP1 is a cytokine that may be induced by apoptosis and is also released from professional antigen-presenting cells such as dendritic cells. The release of AIMP1 renders the tumor-associated vasculature sensitive to tumor necrosis factor. Furthermore, AIMP1 binds tRNA and stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase. This protein possesses inflammatory cytokine activity. Also, AIMP1 negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation.