Neuregulin 4 Protein (NRG4) (AA 1-53) (GST tag)
-
- 抗原 See all Neuregulin 4 (NRG4) 蛋白
- Neuregulin 4 (NRG4)
- 蛋白类型
- Recombinant
- 生物活性
- Active
- 产品特性
- AA 1-53
-
宿主
- 人
-
资源
- 大肠杆菌（E. Coli）
- 标记
- This Neuregulin 4 protein is labelled with GST tag.
- 应用范围
- SDS-PAGE (SDS)
- 交叉反应
- 人
- 产品特性
- Human Neuregulin-4 (aa 1-53) is fused at the N-terminus to GST.
- 纯度
- >95 % (SDS-PAGE)
- 内毒素水平
- <0.01EU/μg purified protein (LAL test, Lonza).
- Top Product
- Discover our top product NRG4 蛋白
-
Neuregulin 4 (NRG4) (AA 1-115) protein (GST tag)
NRG4 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Neuregulin 4 (NRG4) (AA 1-61) protein (His tag)NRG4 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Neuregulin 4 (NRG4) (Active) proteinNRG4 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant >95 % as determined by SDS-PAGE Func Active
-
- 应用备注
- Optimal working dilution should be determined by the investigator.
- 说明
-
Binds to the human receptor tyrosine-protein kinase ErbB4.
- 限制
- 仅限研究用
-
- 状态
- Solid
- 浓度
- Lot specific
- 缓冲液
- Lyophilized. Contains PBS.
- 储存条件
- 4 °C,-20 °C
- 储存方法
-
Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 6 months after receipt when stored at -20°C. - 有效期
- 6 months
-
- 抗原
- Neuregulin 4 (NRG4)
- 别名
- Neuregulin-4 (NRG4 产品)
- 别名
- HRG4 Protein, AI552600 Protein, neuregulin 4 Protein, NRG4 Protein, Nrg4 Protein, LOC100347220 Protein
- 背景
- Neuregulin-4 (Nrg4) belongs to a small family of EGF-like (EGFL) domain-containing proteins that are synthesized as transmembrane precursors and undergo proteolytic cleavage. The EGF-like domain (aa 5-46) of Nrg4 (aa 1-53) directly binds to the receptors ErbB3 and 4. Nrg4 is a cold induced adipokine, highly expressed in adipose tissues and enriched in brown fat. It is increased during brown adipocyte differentiation and reduced in rodent and human obesity. It promotes neurite outgrowth and protects against diet-induced insulin resistance and hepatic steatosis through attenuating hepatic lipogenic signaling. This hepatic effect of Nrg4 is mediated by ErbB3 and ErbB4 signaling that negatively regulates de novo lipogenesis mediated by LXR and SREBP1c. This effect of Nrg4 on fatty liver and insulin resistance could lead to the development of Nrg4 as an effective therapeutic biological for the treatment of NAFLD and type 2 diabetes. GST-Nrg4 (aa 1-53) recombinant protein has been shown to mimic the effect of endogenous secreted Nrg4 on liver lipogenesis.
- 分子量
- ~32kDa (SDS-PAGE)
- UniProt
- Q8WWG1
- 途径
- RTK signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
-
