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IL12A & IL27B (AA 20-189) (Active) protein (His tag)

Name: IL12A & IL27B (AA 20-189) (Active) protein (His tag)
SKU: ABIN4949114
Availability: OutOfStock

宿主: 人宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Func Active

Immobilized Human IL-23 R, Fc Tag (ABIN6731281,ABIN6809891) at 10 μg/mL (100 μL/well) can bind Human IL-23A&IL-12B Heterodimer Protein, His Tag&Tag Free (ABIN4949114,ABIN4949115) with a linear range of 20-78 ng/mL (Routinely tested). (IL12A & IL27B (AA 20-189) (Active) protein (His tag))

ELISA

Human IL-23 alpha & IL-12 beta Heterodimer Protein on SDS-PAGE under reducing (R) condition. (IL12A & IL27B (AA 20-189) (Active) protein (His tag))

SDS

Immobilized Human IL-23A&IL-12B Heterodimer Protein, His Tag&Tag Free (ABIN4949114,ABIN4949115) at 2 μg/mL (100 μL/well) can bind Anti IL23A&IL12B P40 domain, Human IgG1 with a linear range of 0. (IL12A & IL27B (AA 20-189) (Active) protein (His tag))

ELISA

3 images

产品编号 ABIN4949114

发货至: 中国

Datasheet as PDF

抗原

IL12A & IL27B

蛋白类型

Recombinant

生物活性

Active

产品特性

AA 20-189
宿主
4

3

1

1
人
资源
5

1
HEK-293 Cells

标记

His tag

应用范围

Functional Studies (Func)

序列

AA 20-189

产品特性

Human IL-23 alpha & IL-12 beta Heterodimer Protein, produced by co-expression of IL-23 alpha and IL-12 beta, has a calculated MW of 19.5 kDa (IL-23 alpha) and 34.7 kDa (IL-12 beta). Subunit IL-23 alpha is fused with a polyhistidine tag at the N-terminus and subunit IL-12 beta contains no tag. The predicted N-terminus is His (IL23A) & Ile 23 (IL12B). The reducing (R) protein migrates as 20 kDa (IL-23 alpha) and 40-45 kDa (IL-12 beta) respectively due to glycosylation.

纯度

>95 % as determined by SDS-PAGE.

内毒素水平

Less than 1.0 EU per μg by the LAL method.
IL12A & IL27B (AA 20-189) (Active) protein (His tag)
宿主: 人, 大鼠宿主: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active

IL12A & IL27B (AA 22-196) (Active) protein (His tag)
宿主: 小鼠宿主: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Func Active

IL12A & IL27B (AA 20-189) (Active) protein (His tag)
宿主: 人, 小鼠宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Func Active

IL12A & IL27B (AA 20-189) (Active) protein (His tag,AVI tag,Biotin)
宿主: 人宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Func Active

IL12A & IL27B (AA 22-189) (Active) protein (His tag)
宿主: 小鼠, Cynomolgus 宿主: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active

IL12A & IL27B (AA 20-189), (AA 23-328) protein (His tag)
宿主: 人宿主: 人细胞 Recombinant Greater than 95 % as determined by reducing SDS-PAGE. ELISA, MS, SDS, WB

限制

仅限研究用
状态

Lyophilized

缓冲液

PBS, pH 7.4

注意事项

Please avoid repeated freeze-thaw cycles.

储存条件

-20 °C
抗原

IL12A & IL27B

别名

IL23A & IL12B

背景

Interleukin-23 subunit alpha (IL-23 alpha) can associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.

分子量

19.5 kDa (IL23A) & 34.7 kDa (IL12B)