Osteoprotegerin 蛋白
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- 抗原 See all Osteoprotegerin (TNFRSF11B) 蛋白
- Osteoprotegerin (TNFRSF11B) (Tumor Necrosis Factor Receptor Superfamily, Member 11b (TNFRSF11B))
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 人
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资源
- 酵母菌
- 应用范围
- Functional Studies (Func)
- 序列
- ETFPPKYLHY DEETSHQLLC DKCPPGTYLK QHCTAKWKTV CAPCPDHYYT DSWHTSDECL YCSPVCKELQ YVKQECNRTH NRVCECKEGR YLEIEFCLKH RSCPPGFGVV QAGTPERNTV CKRCPDGFFS NETSSKAPCR KHTNCSVFGL LLTQKGNATH DNICSGNSES TQKCGIDVTL EPKSSDKTHT CPPCPAPEFE GAPSVFLFPP KPKDTLMISR TPEVTCVVVD VSHEDPEVKF NWYVDGVEVH NAKTKPREEQ YNSTYRVVSV LTVLHQDWLN GKEYKCKVSN KALPTPIEKT ISKAKGQPRE PQVYTLPPSR DELTKNQVSL TCLVKGFYPS DIAVEWESNG QPENNYKTTP PVLDSDGSFF LYSKLTVDKS RWQQGNVFSC SVMHEALHNH YTQKSLSLSP GK
- 产品特性
- Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by neutralizing the stimulation of U937 cells is less than 10 ng/mL, corresponding to a specific activity of ＞ 1.0 x 105 IU/mg in the presence of 10 ng/mL soluble rHuRANKL (sRANKL
- 纯度
- >95 % as determined by SDS-PAGE and HPLC.
- 过滤
- 0.2 μm filtered
- Top Product
- Discover our top product TNFRSF11B 蛋白
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Tumor Necrosis Factor Receptor Superfamily, Member 11b (TNFRSF11B) (AA 22-401) protein (His tag)
TNFRSF11B 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Tumor Necrosis Factor Receptor Superfamily, Member 11b (TNFRSF11B) (AA 22-401) protein (His tag)TNFRSF11B 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Tumor Necrosis Factor Receptor Superfamily, Member 11b (TNFRSF11B) (AA 24-194) protein (His-DYKDDDDK-Strep II Tag)TNFRSF11B 宿主: 人 宿主: HEK-293T Cells Recombinant SDS, WB, ELISA, PI
Tumor Necrosis Factor Receptor Superfamily, Member 11b (TNFRSF11B) (AA 201-401) protein (His tag)TNFRSF11B 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Tumor Necrosis Factor Receptor Superfamily, Member 11b (TNFRSF11B) (AA 22-401) protein (GST tag)TNFRSF11B 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Tumor Necrosis Factor Receptor Superfamily, Member 11b (TNFRSF11B) protein (Fc Tag)TNFRSF11B 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE
Tumor Necrosis Factor Receptor Superfamily, Member 11b (TNFRSF11B) (AA 22-401) protein (Fc Tag)TNFRSF11B 宿主: 人 宿主: HEK-293 Cells Recombinant >92 % as determined by SDS-PAGE.
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
- 20 mM PB, pH 6.0, 150 mM NaCl, 0.02 % Tween-80
- 储存条件
- -20 °C
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- 抗原
- Osteoprotegerin (TNFRSF11B) (Tumor Necrosis Factor Receptor Superfamily, Member 11b (TNFRSF11B))
- 别名
- TNFRSF11B (TNFRSF11B 产品)
- 别名
- CD254 Protein, ODF Protein, OPGL Protein, OPTB2 Protein, RANKL Protein, TRANCE Protein, hRANKL2 Protein, sOdf Protein, OCIF Protein, OPG Protein, TR1 Protein, Opg Protein, ocif Protein, opg Protein, tr1 Protein, TNF superfamily member 11 Protein, TNF receptor superfamily member 11b Protein, tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) Protein, TNF receptor superfamily member 11B Protein, tumor necrosis factor receptor superfamily member 11b S homeolog Protein, tumor necrosis factor receptor superfamily, member 11b Protein, TNFSF11 Protein, TNFRSF11B Protein, Tnfrsf11b Protein, tnfrsf11b.S Protein
- 物质类
- Chemical
- 背景
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Relevance: Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis. {ECO:0000269|PubMed:22664871, ECO:0000269|PubMed:9168977}.
Synonyms: Osteoclastogenesis inhibitory factor, - 分子量
- 109.6 kDa
- UniProt
- O00300
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