IMPA1 Protein (Transcript Variant 2) (His tag)
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- 抗原 See all IMPA1 蛋白
- IMPA1 (Inositol(myo)-1(or 4)-Monophosphatase 1 (IMPA1))
- 蛋白类型
- Recombinant
- 产品特性
- Transcript Variant 2
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宿主
- 人
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资源
- 大肠杆菌(E. Coli)
- 标记
- This IMPA1 protein is labelled with His tag.
- 应用范围
- Antibody Production (AbP), Standard (STD)
- 产品特性
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- Recombinant human Inositol monophosphatase / IMPA1 (transcript variant 2) protein expressed in E. coli.
- Produced with end-sequenced ORF clone
- 纯度
- > 95 % as determined by SDS-PAGE and Coomassie blue staining
- 内毒素水平
- < 0.1 EU per μg protein as determined by LAL test
- Top Product
- Discover our top product IMPA1 蛋白
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- 应用备注
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - 说明
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The tag is located at the C-terminal.
- 限制
- 仅限研究用
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- 浓度
- 50 μg/mL
- 缓冲液
- 20 mM Phosphate buffer, 150 mM NaCl, pH 7.25. Avoid repeated freeze-thaw cycles. Stable for at least 3 months from receipt of products under proper storage and handling conditions.
- 储存条件
- -80 °C
- 储存方法
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- 抗原
- IMPA1 (Inositol(myo)-1(or 4)-Monophosphatase 1 (IMPA1))
- 别名
- Inositol Monophosphatase,impa1 (IMPA1 产品)
- 别名
- zgc:100926 Protein, 2610002K09Rik Protein, 2900059K10Rik Protein, AI325909 Protein, IMP Protein, IMPA Protein, impa Protein, inositol monophosphatase 1 Protein, inositol(myo)-1(or 4)-monophosphatase 1 Protein, inositol (myo)-1(or 4)-monophosphatase 1 Protein, inositol monophosphatase Protein, inositol(myo)-1(or 4)-monophosphatase 1 S homeolog Protein, impa1 Protein, Impa1 Protein, IMPA1 Protein, impa1.S Protein
- 背景
- This gene encodes an enzyme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2&apos-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13.
- 分子量
- 32.3 kDa
- NCBI登录号
- NP_001138350
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