ACER1 Protein (Myc-DYKDDDDK Tag)
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- 抗原 See all ACER1 蛋白
- ACER1 (Alkaline Ceramidase 1 (ACER1))
- 蛋白类型
- Recombinant
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This ACER1 protein is labelled with Myc-DYKDDDDK Tag.
- 应用范围
- Antibody Production (AbP), Standard (STD)
- 产品特性
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- Recombinant human Alkaline ceramidase 1 protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
- 纯度
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
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Alkaline Ceramidase 1 (ACER1) (AA 1-264) protein (Strep Tag)
Crystallography grade ACER1 宿主: 人 宿主: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, ELISA, SDS
Alkaline Ceramidase 1 (ACER1) (AA 1-273) protein (Strep Tag)Crystallography grade ACER1 宿主: 小鼠 宿主: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, ELISA, SDS
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- 应用备注
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - 说明
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The tag is located at the C-terminal.
- 限制
- 仅限研究用
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- 浓度
- 50 μg/mL
- 缓冲液
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
- 储存条件
- -80 °C
- 储存方法
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- 抗原
- ACER1 (Alkaline Ceramidase 1 (ACER1))
- 别名
- Alkaline Ceramidase 1 (ACER1 产品)
- 别名
- ASAH3 Protein, asah3 Protein, zgc:110285 Protein, ALKCDase1 Protein, 2310024P18Rik Protein, AI662009 Protein, Alkcdase1 Protein, Asah3 Protein, Cer1 Protein, alkaline ceramidase 1 Protein, ACER1 Protein, acer1 Protein, Acer1 Protein
- 背景
- Ceramides are synthesized during epidermal differentiation and accumulate within the interstices of the stratum corneum, where they represent critical components of the epidermal permeability barrier. Excess cellular ceramide can trigger antimitogenic signals and induce apoptosis, and the ceramide metabolites sphingosine and sphingosine-1-phosphate (S1P) are important bioregulatory molecules. Ceramide hydrolysis in the nucleated cell layers regulates keratinocyte proliferation and apoptosis in response to external stress. Ceramide hydrolysis also occurs at the stratum corneum, releasing free sphingoid base that functions as an endogenous antimicrobial agent. ACER1 is highly expressed in epidermis and catalyzes the hydrolysis of very long chain ceramides to generate sphingosine (Houben et al., 2006 [PubMed 16477081] Sun et al., 2008 [PubMed 17713573]).[supplied by OMIM, Jul 2010].
- 分子量
- 30.9 kDa
- NCBI登录号
- NP_597999
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