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ACER1 蛋白

(Alkaline Ceramidase 1 (ACER1))
Ceramides are synthesized during epidermal differentiation and accumulate within the interstices of the stratum corneum, where they represent critical components of the epidermal permeability barrier. Excess cellular ceramide can trigger antimitogenic signals and induce apoptosis, and the ceramide metabolites sphingosine and sphingosine-1-phosphate (S1P) are important bioregulatory molecules. Ceramide hydrolysis in the nucleated cell layers regulates keratinocyte proliferation and apoptosis in response to external stress. Ceramide hydrolysis also occurs at the stratum corneum, releasing free sphingoid base that functions as an endogenous antimicrobial agent. ACER1 is highly expressed in epidermis and catalyzes the hydrolysis of very long chain ceramides to generate sphingosine (Houben et al., 2006 [PubMed 16477081]\; Sun et al., 2008 [PubMed 17713573]).[supplied by OMIM, Jul 2010].
ACER1 Protein (AA 1-264) (rho-1D4 tag) ACER1 Protein (AA 1-264) (rho-1D4 tag) ACER1 Protein (AA 1-264) (rho-1D4 tag) (ABIN3104294)

Crystallography grade ACER1 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, Crys, ELISA

ACER1 Protein (AA 1-273) (rho-1D4 tag) ACER1 Protein (AA 1-273) (rho-1D4 tag) ACER1 Protein (AA 1-273) (rho-1D4 tag) (ABIN3126824)

Crystallography grade ACER1 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, Crys, ELISA

ACER1 Protein (Myc-DYKDDDDK Tag) ACER1 Protein (Myc-DYKDDDDK Tag) ACER1 Protein (Myc-DYKDDDDK Tag) (ABIN2714568)

ACER1 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD

ACER1 蛋白 by Grade

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ACER1 蛋白 by Origin

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ACER1 蛋白 by Source

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Popular ACER1 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3104294
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3126824
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN2714568
Quantity 20 μg
Datasheet Datasheet

Aliases for ACER1 蛋白

alkaline ceramidase 1 (ACER1) 蛋白
alkaline ceramidase 1 (acer1) 蛋白
alkaline ceramidase 1 (Acer1) 蛋白
2310024P18Rik 蛋白
AI662009 蛋白
ALKCDase1 蛋白
Alkcdase1 蛋白
ASAH3 蛋白
asah3 蛋白
Asah3 蛋白
Cer1 蛋白
zgc:110285 蛋白
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