CIB1 Protein (Myc-DYKDDDDK Tag)
-
- 抗原 See all CIB1 蛋白
- CIB1 (Calcium and Integrin-Binding Protein 1 (CIB1))
- 蛋白类型
- Recombinant
-
宿主
- 人
-
资源
- HEK-293 Cells
- 标记
- This CIB1 protein is labelled with Myc-DYKDDDDK Tag.
- 应用范围
- Antibody Production (AbP), Standard (STD)
- 产品特性
-
- Recombinant human CIB1 protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
- 纯度
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
- Top Product
- Discover our top product CIB1 蛋白
-
Calcium and Integrin-Binding Protein 1 (CIB1) (AA 1-191) protein (His tag)
CIB1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % by SDS - PAGE SDS
Calcium and Integrin-Binding Protein 1 (CIB1) (AA 1-191) protein (GST tag)CIB1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Calcium and Integrin-Binding Protein 1 (CIB1) (AA 2-191) protein (His tag)Crystallography grade CIB1 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
-
- 应用备注
-
Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - 说明
-
The tag is located at the C-terminal.
- 限制
- 仅限研究用
-
- 浓度
- 50 μg/mL
- 缓冲液
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
- 储存条件
- -80 °C
- 储存方法
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
-
- 抗原
- CIB1 (Calcium and Integrin-Binding Protein 1 (CIB1))
- 别名
- Cib1 (CIB1 产品)
- 别名
- zgc:112015 Protein, CIB Protein, CIBP Protein, KIP1 Protein, PRKDCIP Protein, SIP2-28 Protein, Cibkip Protein, Kip Protein, Prkdcip Protein, Cib Protein, Sip2-28 Protein, calcium and integrin binding 1 (calmyrin) Protein, calcium and integrin-binding protein 1 Protein, calcium and integrin binding 1 Protein, Calcium and integrin-binding protein 1 Protein, cib1 Protein, CpipJ_CPIJ003501 Protein, CIB1 Protein, kip1 Protein, Cib1 Protein
- 背景
- Calcium-binding protein that plays a role in the regulation of numerous cellular processes, such as cell differentiation, cell division, cell proliferation, cell migration, thrombosis, angiogenesis, cardiac hypertrophy and apoptosis. Involved in bone marrow megakaryocyte differentiation by negatively regulating thrombopoietin-mediated signaling pathway. Participates in the endomitotic cell cycle of megakaryocyte, a form of mitosis in which both karyokinesis and cytokinesis are interrupted. Plays a role in integrin signaling by negatively regulating alpha-IIb/beta3 activation in thrombin-stimulated megakaryocytes preventing platelet aggregation. Up-regulates PTK2/FAK1 activity, and is also needed for the recruitment of PTK2/FAK1 to focal adhesions it thus appears to play an important role in focal adhesion formation. Positively regulates cell migration on fibronectin in a CDC42-dependent manner, the effect being negatively regulated by PAK1. Functions as a negative regulator of stress activated MAP kinase (MAPK) signaling pathways. Down-regulates inositol 1,4,5-trisphosphate receptor-dependent calcium signaling. Involved in sphingosine kinase SPHK1 translocation to the plasma membrane in a N-myristoylation-dependent manner preventing TNF-alpha-induced apoptosis. Regulates serine/threonine-protein kinase PLK3 activity for proper completion of cell division progression. Plays a role in microtubule (MT) dynamics during neuronal development disrupts the MT depolymerization activity of STMN2 attenuating NGF-induced neurite outgrowth and the MT reorganization at the edge of lamellipodia. Promotes cardiomyocyte hypertrophy via activation of the calcineurin/NFAT signaling pathway. Stimulates calcineurin PPP3R1 activity by mediating its anchoring to the sarcolemma. In ischemia-induced (pathological or adaptive) angiogenesis, stimulates endothelial cell proliferation, migration and microvessel formation by activating the PAK1 and ERK1/ERK2 signaling pathway. Promotes also ca [UniProtKB/Swiss-Prot Function]
- 分子量
- 21.5 kDa
- NCBI登录号
- NP_006375
-
