Leptin Receptor Protein (LEPR) (Fc Tag)
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- 抗原 See all Leptin Receptor (LEPR) 蛋白
- Leptin Receptor (LEPR)
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This Leptin Receptor protein is labelled with Fc Tag.
- 应用范围
- Western Blotting (WB)
- 产品特性
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Measured by its ability to inhibit Leptin-dependent proliferation of BaF3 mouse pro-B cells transfected with rhLEPR-Fc. The ED50 for this effect is typically 0. 015-0. 13 μg/mL in the presence of 3 ng/mL rhLeptin.
Fusion tag: C-Fc Tag
- 纯度
- >95 % as determined by SDS-PAGE.
- Top Product
- Discover our top product LEPR 蛋白
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Leptin Receptor (LEPR) protein (Fc Tag)
LEPR 宿主: 人 宿主: 人细胞 Recombinant >95 % as determined by reducing SDS-PAGE.
Leptin Receptor (LEPR) (AA 22-839) protein (His tag)LEPR 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Leptin Receptor (LEPR) protein (Fc Tag)LEPR 宿主: 小鼠 宿主: 人细胞 Recombinant >95 % as determined by reducing SDS-PAGE.
Leptin Receptor (LEPR) (AA 31-130) protein (GST tag)LEPR 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Leptin Receptor (LEPR) protein (mFc Tag)LEPR 宿主: 小鼠 宿主: 人细胞 Recombinant >95 % as determined by reducing SDS-PAGE.
Leptin Receptor (LEPR) protein (His tag)LEPR 宿主: 小鼠 宿主: 人细胞 Recombinant >90 % as determined by reducing SDS-PAGE.
Leptin Receptor (LEPR) (AA 863-1165) protein (His tag)Crystallography grade LEPR 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Leptin Receptor (LEPR) (AA 861-1162) protein (His tag)Crystallography grade LEPR 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Leptin Receptor (LEPR) (AA 22-839) protein (His tag)Crystallography grade LEPR 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Leptin Receptor (LEPR) (AA 22-839) protein (His tag)Crystallography grade LEPR 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
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- 应用备注
- This recombinant protein can be used for WB. For research use only.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
- PBS, pH 7.4
- 储存条件
- -80 °C,-20 °C
- 储存方法
- Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
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- 抗原
- Leptin Receptor (LEPR)
- 别名
- LEPR (LEPR 产品)
- 别名
- CD295 Protein, LEP-R Protein, LEPRD Protein, OB-R Protein, OBR Protein, obr Protein, cd295 Protein, ob-rb Protein, Fa Protein, LEPROT Protein, Leprb Protein, Modb1 Protein, OB-RGRP Protein, Obr Protein, db Protein, diabetes Protein, obese-like Protein, obl Protein, ObRb Protein, Ob-R Protein, Ob-RM Protein, lepr Protein, leptin receptor Protein, leptin receptor S homeolog Protein, LEPR Protein, lepr Protein, Lepr Protein, lepr.S Protein
- 背景
- Leptin receptor (LEPR) is also known as LEP-R, cluster of differentiation 295 (CD295), OB-R and B219, is a single-transmembrane-domain receptor of the gp130 family of cytokine receptors. Leptin receptor exists as homodimer and binds Leptin with high affinity, thus mediates the biological function of the adipocyte-specific hormone Leptin. LEPR is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this protein have been associated with obesity and pituitary dysfunction. Interaction of leptin and leptin receptor is crucial for body weight and bone mass regulation in mammals through hypothalamic effects on satiety and energy expenditure. Meanwhile, research data supports a leptin receptor activation model based on ligand-induced conformational changes.
- 分子量
- 121 kDa
- 基因ID
- 3953
- NCBI登录号
- NP_002294
- UniProt
- P48357
- 途径
- JAK/STAT Signaling, AMPK Signaling, Feeding Behaviour
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