Leptin Receptor Protein (LEPR) (mFc Tag)
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- 抗原 See all Leptin Receptor (LEPR) 蛋白
- Leptin Receptor (LEPR)
- 蛋白类型
- Recombinant
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宿主
- 小鼠
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资源
- 人细胞
- 标记
- This Leptin Receptor protein is labelled with mFc Tag.
- 原理
- Recombinant Mouse Leptin Receptor/LEPR/CD295 (C-mFc)
- 序列
- Leu22-Gly839
- 产品特性
- Recombinant Mouse Leptin Receptor is produced by our Mammalian expression system and the target gene encoding Leu22-Gly839 is expressed with a mFc tag at the C-terminus.
- 纯度
- >95 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product LEPR 蛋白
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Leptin Receptor (LEPR) protein (Fc Tag)
LEPR 宿主: 人 宿主: 人细胞 Recombinant >95 % as determined by reducing SDS-PAGE.
Leptin Receptor (LEPR) (AA 22-839) protein (His tag)LEPR 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Leptin Receptor (LEPR) protein (Fc Tag)LEPR 宿主: 小鼠 宿主: 人细胞 Recombinant >95 % as determined by reducing SDS-PAGE.
Leptin Receptor (LEPR) (AA 31-130) protein (GST tag)LEPR 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Leptin Receptor (LEPR) protein (His tag)LEPR 宿主: 小鼠 宿主: 人细胞 Recombinant >90 % as determined by reducing SDS-PAGE.
Leptin Receptor (LEPR) (AA 863-1165) protein (His tag)Crystallography grade LEPR 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Leptin Receptor (LEPR) (AA 861-1162) protein (His tag)Crystallography grade LEPR 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Leptin Receptor (LEPR) (AA 22-839) protein (His tag)Crystallography grade LEPR 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Leptin Receptor (LEPR) (AA 22-839) protein (His tag)Crystallography grade LEPR 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Leptin Receptor (LEPR) (AA 22-1165) protein (rho-1D4 tag)Crystallography grade LEPR 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- Leptin Receptor (LEPR)
- 别名
- Leptin Receptor/LEPR/CD295 (LEPR 产品)
- 别名
- CD295 Protein, LEP-R Protein, LEPRD Protein, OB-R Protein, OBR Protein, obr Protein, cd295 Protein, ob-rb Protein, Fa Protein, LEPROT Protein, Leprb Protein, Modb1 Protein, OB-RGRP Protein, Obr Protein, db Protein, diabetes Protein, obese-like Protein, obl Protein, ObRb Protein, Ob-R Protein, Ob-RM Protein, lepr Protein, leptin receptor Protein, leptin receptor S homeolog Protein, LEPR Protein, lepr Protein, Lepr Protein, lepr.S Protein
- 背景
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Background: The Leptin receptor is a member of the Class I cytokine receptor family. It mediates the activities of Leptin, a multi-functional hormone produced primarily by adipose tissues that plays roles in food intake, energy metabolism, angiogenesis, reproduction, hematopoiesis, bone metabolism, and immune function. The human Leptin R gene encodes 1165 amino acids (aa) including a signal peptide, an extracellular region with cytokine receptor homology (CRH), multiple fibronectin type III domains and a WSXWS motif, a transmembrane domain, and a cytoplasmic domain that supports JAK/STAT signaling. Soluble Leptin R is the primary Leptin-binding protein in blood, where it maintains a pool of available bioactive Leptin, delays Leptin clearance from circulation, and down-regulates blood-brain transmission of Leptin. In humans, soluble Leptin R levels are inversely proportional to adiposity and are elevated in females versus males. Soluble Leptin R is also found up-regulated in patients with chronic heart failure, end-stage renal disease, and anorexia.It is expressed by tumor-initiating stem cells, and is proposed as a link between cancer and obesity.
Synonym: Leptin receptor, LEP-R, HuB219, OB receptor, OB-R, CD295, LEPR, DB, OBR
- 分子量
- 118.5 kDa
- UniProt
- P48356
- 途径
- JAK/STAT Signaling, AMPK Signaling, Feeding Behaviour
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