IL1R2 Protein (His tag)
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- 抗原 See all IL1R2 蛋白
- IL1R2 (Interleukin 1 Receptor, Type II (IL1R2))
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This IL1R2 protein is labelled with His tag.
- 应用范围
- Western Blotting (WB)
- 产品特性
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Measured by its ability to inhibit IL-1 beta dependent proliferation in D10. G4. 1 mouse helper T cells. Approximately 0. 5-3 μg/mL of IL1R2 will inhibit 50 % of the biological response due to 50 pg/mL of recombinant human IL-1 beta.
- 纯度
- >98 % as determined by SDS-PAGE.
- Top Product
- Discover our top product IL1R2 蛋白
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- 应用备注
- This recombinant protein can be used for WB. For research use only.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
- PBS, pH 7.4
- 储存条件
- -80 °C,-20 °C
- 储存方法
- Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
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- 抗原
- IL1R2 (Interleukin 1 Receptor, Type II (IL1R2))
- 别名
- IL 1 R2 (IL1R2 产品)
- 别名
- CD121b Protein, CDw121b Protein, IL-1R-2 Protein, IL-1RT-2 Protein, IL-1RT2 Protein, IL1R2c Protein, IL1RB Protein, Il1r-2 Protein, IL-1R2 Protein, interleukin 1 receptor type 2 Protein, interleukin 1 receptor, type II Protein, interleukin-like Protein, IL1R2 Protein, Il1r2 Protein, KK34 Protein
- 背景
- Interleukin-1 receptor type 2 (IL1R2) is also known as CD121 antigen-like family member B (CDw121b), IL-1 type II receptor, Interleukin-1 receptor type II, belongs to the interleukin-1 receptor family. Two distinct types of IL1 receptors which are able to bind IL1 specifically have been identified, designated as IL1RI (IL1RA) and IL1RII (IL1RB). IL1R2 is non-signaling receptor for IL1A, IL1B and IL1RN, reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. IL1R2 modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity, this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.
- 分子量
- 38.6 kDa
- 基因ID
- 7850
- NCBI登录号
- NP_004624
- UniProt
- P27930
- 途径
- NF-kappaB Signaling
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