WNT7A 蛋白
WNT7A
宿主: 人
宿主: HEK-293 Cells
Recombinant
< 80 % by SDS-PAGE gel and HPLC analyses.
Active
-
- 抗原 See all WNT7A 蛋白
- WNT7A (Wingless-Type MMTV Integration Site Family, Member 7A (WNT7A))
- 蛋白类型
- Recombinant
- 生物活性
- Active
-
宿主
- 人
-
资源
- HEK-293 Cells
- 序列
- LGASIICNKI PGLAPRQRAI CQSRPDAIIV IGEGSQMGLD ECQFQFRNGR WNCSALGERT VFGKELKVGS REAAFTYAII AAGVAHAITA ACTQGNLSDC GCDKEKQGQY HRDEGWKWGG CSADIRYGIG FAKVFVDARE IKQNARTLMN LHNNEAGRKI LEENMKLECK CHGVSGSCTT KTCWTTLPQF RELGYVLKDK YNEAVHVEPV RASRNKRPTF LKIKKPLSYR KPMDTDLVYI EKSPNYCEED PVTGSVGTQG RACNKTAPQA SGCDLMCCGR GYNTHQYARV WQCNCKFHWC CYVKCNTCSE RTEMYTCK
- 产品特性
- Biological activity was determined by its ability to inhibit Wnt3a induced alkaline phosphatase production in MC3T3-E1 cells. The expected ED50 for this effect is 40-60 ng/mL.
- 纯度
- < 80 % by SDS-PAGE gel and HPLC analyses.
- Top Product
- Discover our top product WNT7A 蛋白
-
Wingless-Type MMTV Integration Site Family, Member 7A (WNT7A) (AA 32-349) protein (His tag)
WNT7A 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 85 % by SDS - PAGE SDS
-
- 限制
- 仅限研究用
-
- 状态
- Lyophilized
- 注意事项
- As with any protein, exposing WNT-7A recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
- 储存条件
- -20 °C
- 储存方法
- The recombinant protein is stable for at least 2 years from date of receipt at -20 °C. Reconstituted WNT-7A stable for at least 3 months when stored in working aliquots with a carrier protein at -20 °C.
- 有效期
- 24 months
-
- 抗原
- WNT7A (Wingless-Type MMTV Integration Site Family, Member 7A (WNT7A))
- 别名
- WNT-7A (WNT7A 产品)
- 别名
- wnt7a Protein, AI849442 Protein, Wnt-7a Protein, px Protein, tw Protein, Xwnt-7a Protein, wnt-7a Protein, wnt7a-A Protein, Wnt family member 7A Protein, wingless-type MMTV integration site family, member 7Aa Protein, wingless-type MMTV integration site family, member 7A Protein, wingless-type MMTV integration site family member 7A S homeolog Protein, WNT7A Protein, wnt7aa Protein, Wnt7a Protein, wnt7a.S Protein
- 背景
- Wnt-7a belongs to the Wnt family of signaling proteins that play a key role in maintaining the integrity of embryonic and adult tissues. It is expressed in placenta, kidney, testis, uterus, fetal lung and fetal and adult brain. Most Wnt proteins can signal though a mechanism called the canonical Wnt pathway, in which Wnt proteins bind to and activate seven-pass transmembrane receptors of the Frizzled family ultimately leading to the disruption of ?-Catenein degradation. Intracellular accumulation of beta-Catenin increases translocation of the protein into the nucleus where it binds to TCF/LEF transcription factors and induces the expression of numerous genes. Increased Wnt/?-Catenein signaling is associated with tumorigenesis in a diverse set of human cancers. However, Wnt-7a/Frizzled-9 signaling has been shown to act as a tumor suppressor in non-small cell lung cancers. Recombinant human Wnt-7a is a 35.5 kDa glycoprotein containing 318 amino acids. Due to glycosylation, Wnt-7a migrates between 40-55 kDa by SDS-PAGE gel under unreduced conditions.
- 基因ID
- 7476
- NCBI登录号
- NP_004616
- OMIM
- 17505191
- UniProt
- O00755
- 途径
- WNT signaling, Stem Cell Maintenance, Asymmetric Protein Localization
-
You are here:
