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IL-6 Protein (AA 30-212)

This Recombinant IL-6 protein is expressed in HEK-293 Cells and has been mentioned in 4+ publications.

SDS-PAGE (SDS) image for Interleukin 6 (IL6) (AA 30-212) (Active) protein (ABIN2181322) (IL-6 Protein (AA 30-212))

Immobilized Human IL-6, Tag Free (ABIN2181322,ABIN3071739) at 5 μg/mL (100 μL/well) can bind Biotinylated Human IL-6 R alpha, Avitag,His Tag (ABIN5526620,ABIN5526621) with a linear range of 4-125 ng/mL (QC tested). (IL-6 Protein (AA 30-212))

2 images

(4 references)

产品编号 ABIN2181322

发货至: 中国

Quick Overview for IL-6 Protein (AA 30-212) (ABIN2181322)

抗原

See all IL-6 (IL6) 蛋白

IL-6 (IL6) (Interleukin 6 (IL6))

蛋白类型

Recombinant

生物活性

Active

宿主

38
21
14
5
4
4
4
4
4
4
3
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1

人

资源

57
24
19
8
6
4
1
1
1

HEK-293 Cells

纯度

>90 % as determined by SDS-PAGE.

Discover our top product IL6 蛋白

产品特性

AA 30-212

品牌

ActiveMax®

序列

AA 30-212

产品特性

This protein carries no "tag". The protein has a calculated MW of 20.8 kDa. The protein migrates as 24-27 kDa under reducing (R) condition (SDS-PAGE) due to different glycosylation.

过滤

0.22 μm filtered

内毒素水平

Less than 1.0 EU per μg by the LAL method.
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Interleukin 6 (IL6) (AA 30-212) protein (mFc-His Tag)
IL6 宿主: 人宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. ELISA, FACS

Interleukin 6 (IL6) (AA 30-212) protein
IL6 宿主: 人宿主: 大肠杆菌（E. Coli） Recombinant > 95 % as determined by Tris-Bis PAGE,> 90 % as determined by HPLC

Interleukin 6 (IL6) (AA 28-212) protein (His tag)
IL6 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

Interleukin 6 (IL6) (AA 29-212) (Active) protein
IL6 宿主: 人宿主: 大肠杆菌（E. Coli） Recombinant > 95 % by SDS-PAGE analysis. Active

Interleukin 6 (IL6) (AA 25-211) (Active) protein (His tag)
IL6 宿主: 小鼠宿主: CHO Cells Recombinant > 95 % as analyzed by SDS-PAGE. Active

Interleukin 6 (IL6) (AA 30-212) (Active) protein (His tag)
IL6 宿主: 人宿主: HEK-293 Cells > 97 % AcA, CC Active

Interleukin 6 (IL6) (Active) protein
IL6 宿主: 人宿主: 大肠杆菌（E. Coli） Recombinant > 98 % by SDS-PAGE Active

Interleukin 6 (IL6) (AA 30-208) protein (His tag)
IL6 宿主: 山羊宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA

Interleukin 6 (IL6) (AA 21-207) protein (His tag)
IL6 宿主: 犬宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA

Interleukin 6 (IL6) (AA 25-211) protein (His tag)
IL6 宿主: 大鼠宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA

限制

仅限研究用
状态

Lyophilized

缓冲液

PBS, pH 7.4

注意事项

Please avoid repeated freeze-thaw cycles.

储存条件

-20 °C

储存方法

No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Gao, Lu, Guo, Xin: "Dual-optofluidic waveguide in-line fiber biosensor for real-time label-free detection of interferon-gamma with temperature compensation." in: Optics express, Vol. 28, Issue 7, pp. 10491-10504, (2021) (PubMed).

Lichtor, Chen, Elowe, Chen, Liu: "Side chain determinants of biopolymer function during selection and replication." in: Nature chemical biology, Vol. 15, Issue 4, pp. 419-426, (2019) (PubMed).

Hao, Pan, Huang, Wang, Zhao: "Sensitive detection of lung cancer biomarkers using an aptameric graphene-based nanosensor with enhanced stability." in: Biomedical microdevices, Vol. 21, Issue 3, pp. 65, (2019) (PubMed).

Hao, Pan, Shao, Lin, Zhao: "Graphene-based fully integrated portable nanosensing system for on-line detection of cytokine biomarkers in saliva." in: Biosensors & bioelectronics, Vol. 134, pp. 16-23, (2019) (PubMed).
抗原

IL-6 (IL6) (Interleukin 6 (IL6))

别名

IL-6

背景

Interleukin 6 (IL-6) is also known as HGF, BSF2,HSF, IFNB2 and IL-6, originally identified as a B cell differentiation factor, is a multifunctional cytokine that regulates immune responses, hematopoiesis, acute phase responses, and inflammatory reactions.It is secreted by T cells, macrophages , monocytes, fibroblasts,endothelial cells,et.al. to stimulate immune response to trauma, especially burns or other tissue damage leading to inflammation. Interleukin 6 has been shown to interact with interleukin-6 receptor and glycoprotein. IL-6 is relevant to many disease processes such as diabetes,atherosclerosis, depression,Alzheimer's Disease,systemic,lupus erythematosus,prostate cancer and rheumatoid arthritis. Advanced/metastatic cancer patients have higher levels of IL-6 in their blood.Hence there is an interest in developing anti-IL-6 agents as therapy against many of these diseases.

分子量

20.8 kDa

NCBI登录号

NP_000591

途径

TLR signaling, Hormone Transport, Negative Regulation of Hormone Secretion, Myometrial Relaxation and Contraction, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Regulation of Carbohydrate Metabolic Process, Autophagy, Cell RedoxHomeostasis, Cancer Immune Checkpoints, Inflammasome

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