EGFR Protein (AA 25-645) (Fc Tag)
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- 抗原 See all EGFR 蛋白
- EGFR (Epidermal Growth Factor Receptor (EGFR))
- 蛋白类型
- Recombinant
- 生物活性
- Active
- 产品特性
- AA 25-645
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This EGFR protein is labelled with Fc Tag.
- 序列
- AA 25-645
- 产品特性
- This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 95 kDa. The protein migrates as 130-140 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
- 纯度
- >95 % as determined by SDS-PAGE.
- 过滤
- 0.22 μm filtered
- 内毒素水平
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product EGFR 蛋白
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
- PBS, pH 7.4
- 注意事项
- Please avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
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Generation of a canine anti-EGFR (ErbB-1) antibody for passive immunotherapy in dog cancer patients." in: Molecular cancer therapeutics, Vol. 13, Issue 7, pp. 1777-90, (2014) (PubMed).
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Generation of a canine anti-EGFR (ErbB-1) antibody for passive immunotherapy in dog cancer patients." in: Molecular cancer therapeutics, Vol. 13, Issue 7, pp. 1777-90, (2014) (PubMed).
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- 抗原
- EGFR (Epidermal Growth Factor Receptor (EGFR))
- 别名
- EGF R (EGFR 产品)
- 背景
- The epidermal growth factor receptor (EGFR, ErbB-1, HER1 in humans) is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB-1), HER2/c-neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). Mutations affecting EGFR expression or activity could result in cancer.
- 分子量
- 94.7 kDa
- NCBI登录号
- NP_005219
- 途径
- NF-kappaB Signaling, RTK signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Stem Cell Maintenance, Hepatitis C, Positive Regulation of Response to DNA Damage Stimulus, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling, EGFR Downregulation, S100 Proteins
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