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CD33 Protein (CD33) (AA 18-259) (His tag)

CD33 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
产品编号 ABIN2180756
发货至: 中国
  • 抗原 See all CD33 蛋白
    CD33
    蛋白类型
    Recombinant
    生物活性
    Active
    产品特性
    AA 18-259
    宿主
    • 35
    • 7
    • 1
    • 1
    资源
    • 29
    • 6
    • 3
    • 3
    • 2
    • 1
    HEK-293 Cells
    标记
    This CD33 protein is labelled with His tag.
    序列
    AA 18-259
    产品特性
    This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 27.6 kDa. The protein migrates as 40-45 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
    纯度
    >95 % as determined by SDS-PAGE.
    过滤
    0.22 μm filtered
    内毒素水平
    Less than 1.0 EU per μg by the LAL method.
    Top Product
    Discover our top product CD33 蛋白
  • 限制
    仅限研究用
  • 状态
    Lyophilized
    缓冲液
    PBS, pH 7.4
    注意事项
    Please avoid repeated freeze-thaw cycles.
    储存条件
    -20 °C
    储存方法
    No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C-8 °C), After reconstitution under sterile conditions for 1 month (4 °C-8 °C) or 3 months (-20 °C to -70 °C).
  • 抗原
    CD33
    别名
    Siglec-3 (CD33 产品)
    别名
    SIGLEC-3 Protein, SIGLEC3 Protein, p67 Protein, Siglec-3 Protein, gp67 Protein, CD33 molecule Protein, CD33 antigen Protein, CD33 Protein, Cd33 Protein
    背景
    Myeloid cell surface antigen CD33 is also known as SIGLEC3, Siglecs (sialic acid binding Ig-like lectins) and GP67, is a single-pass type I membrane protein which belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. Human CD33 / Siglec-3 cDNA encodes a 364 amino acid (aa) polypeptide with a hydrophobic signal peptide, an N--terminal Ig--like V--type domain, one Ig--like C2--type domains, a transmembrane region and a cytoplasmic tail. CD33 / Siglec-3 usually considered myeloid-specific, but it can also be found on some lymphoid cells. In the immune response, CD33 / Siglec-3 may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. CD33 / Siglec-3 induces apoptosis in acute myeloid leukemia.
    分子量
    27.6 kDa
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