IL6RA 蛋白
Quick Overview for IL6RA 蛋白 (ABIN2130109)
抗原
See all IL6RA 蛋白蛋白类型
生物活性
宿主
资源
纯度
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序列
- LAPRRCPAQE VARGVLTSLP GDSVTLTCPG VEPEDNATVH WVLRKPAAGS HPSRWAGMGR RLLLRSVQLH DSGNYSCYRA GRPAGTVHLL VDVPPEEPQL SCFRKSPLSN VVCEWGPRST PSLTTKAVLL VRKFQNSPAE DFQEPCQYSQ ESQKFSCQLA VPEGDSSFYI VSMCVASSVG SKFSKTQTFQ GCGILQPDPP ANITVTAVAR NPRWLSVTWQ DPHSWNSSFY RLRFELRYRA ERSKTFTTWM VKDLQHHCVI HDAWSGLRHV VQLRAQEEFG QGEWSEWSPE AMGTPWTESR SPPAENEVST PMQALTTNKD DDNILFRDSA NATSLPVQD
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产品特性
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Purified recombinant Human IL6 R alpha protein
Expression System: HEK cells
Bioactivity: The ED50 was determined by its ability to intensify the IL-6 induced growth inhibition of Mouse M1 cells is ? 5.0 ng/mL, in the presence of 20 ng/mL of rhIL-6. -
内毒素水平
- < 0.1 ng per μg (1 EU/μg).
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Interleukin 6 Receptor, alpha (IL6RA) (AA 20-365) protein (His-Avi Tag)
IL6RA 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Interleukin 6 Receptor, alpha (IL6RA) (AA 20-365) protein (His-Avi Tag,Biotin)IL6RA 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Interleukin 6 Receptor, alpha (IL6RA) (AA 20-365) protein (Fc Tag)IL6RA 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Interleukin 6 Receptor, alpha (IL6RA) (AA 20-365) (Active) protein (His tag)IL6RA 宿主: 人 宿主: HEK-293 Cells Recombinant >92 % as determined by SDS-PAGE. Active
Interleukin 6 Receptor, alpha (IL6RA) protein (His tag)IL6RA 宿主: 小鼠 宿主: 人细胞 Recombinant >95 % as determined by reducing SDS-PAGE.
Interleukin 6 Receptor, alpha (IL6RA) (Active) protein (His tag,ECD)IL6RA 宿主: 大鼠 宿主: HEK-293 Cells Recombinant > 90 % as determined by SDS-PAGE Active
Interleukin 6 Receptor, alpha (IL6RA) protein (Fc Tag,ECD)IL6RA 宿主: 大鼠 宿主: HEK-293 Cells Recombinant > 90 % as determined by SDS-PAGE
Interleukin 6 Receptor, alpha (IL6RA) (AA 20-365) (Active) protein (Fc Tag)IL6RA 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Interleukin 6 Receptor, alpha (IL6RA) (AA 20-357) (Active) protein (His tag,AVI tag,Biotin)IL6RA 宿主: 小鼠 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Interleukin 6 Receptor, alpha (IL6RA) (AA 20-365) (Active) protein (His tag,AVI tag,Biotin)IL6RA 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
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应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
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说明
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Biological activity: The ED50 was determined by its ability to intensify the IL-6 induced growth inhibition of Mouse M1 cells is approx. 5.0 ng/mL, in the presence of 20 ng/mL of rhIL-6.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Reconstitute in 1 PBS to a concentration of 0.1-1.0 mg/mL. When dissolved, dilute further into aqueous buffered solutions.
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缓冲液
- Lyophilized from 1x PBS.
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注意事项
- Avoid repeated freeze/thaw cycles.
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储存条件
- RT/-20 °C
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- IL6RA (Interleukin 6 Receptor, alpha (IL6RA))
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别名
- IL6R alpha
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背景
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IL6 mediates its biological effects through the type I IL6 receptor system that consists of two chains, IL6Ra and gp130. The IL6Ra chain is the binding component specific to IL6, while the gp130 only transmits signals of IL6 when bound to IL6Ra. The gp130 also can transmit signals from LIF, OSM, CNTF, IL11 and CT-1 in conjunction with other receptor subunits. The low-affinity binding site for IL6 is composed of IL6Ra alone. IL6Ra is expressed in a wide range of cells including T cells, fibroblasts and macrophages. Soluble IL6Ra which consists of only the extracellular domain of the IL6Ra chain, acts as an agonist of IL6 activity at low concentrations.
Alternative Names: B cell stimulatory factor-2 protein, soluble IL-6 receptor alpha protein, IL-6, IL6, Interleukin 6R alpha protein, CD126 protein, IL-6R alpha protein, IL-6 protein, IL 6 protein, IL 6 -
分子量
- 37.6 kDa
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途径
- JAK/STAT Signaling, Autophagy, Growth Factor Binding, Cancer Immune Checkpoints
抗原
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