ESM1 Protein (His tag)
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- 抗原 See all ESM1 蛋白
- ESM1 (Endothelial Cell-Specific Molecule 1 (ESM1))
- 蛋白类型
- Recombinant
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宿主
- 小鼠
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资源
- Insect Cells
- 标记
- This ESM1 protein is labelled with His tag.
- 序列
- WSAKYAVDCP EHCDKTECRS SLRCKRTVLD DCGCCQVCAA GPGETCYRTV SGMDGVKCGP GLKCHFYSEE DDFGDEFGIC KDCPYGTFGM ECKETCNCQS GICDRVTGRC LDFPFFQYAA AKSPSRTSAS HTERDSASGD GNAVREEIGE GNAARPSVMK WLNPRTRHHH HHH
- 产品特性
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Length (AA): 173
Chromosomal location: 13 D2.2, 13 - 纯度
- > 95 % by SDS-PAGE. Visualized by silver stain
- Top Product
- Discover our top product ESM1 蛋白
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Endothelial Cell-Specific Molecule 1 (ESM1) protein (His tag)
ESM1 宿主: 小鼠 宿主: 人细胞 Recombinant > 95 % as determined by SDS-PAGE
Endothelial Cell-Specific Molecule 1 (ESM1) (AA 1-184) protein (GST tag)ESM1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Endothelial Cell-Specific Molecule 1 (ESM1) (AA 85-184) protein (GST tag)ESM1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Endothelial Cell-Specific Molecule 1 (ESM1) protein (His tag)ESM1 宿主: 小鼠 宿主: Baculovirus infected Insect Cells Recombinant > 95 % as determined by SDS-PAGE
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- 应用备注
- Not tested so far.
- 说明
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Cytokines & Growth Factors
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Mouse Endocan/ESM-1 should be reconstituted in water to a concentration of 0.1 mg/mL. This solution can be diluted in water or other buffer solutions or stored at -20 °C.
- 缓冲液
- water
- 储存条件
- 0 °C
- 储存方法
- The lyophilized mouse Endocan/ESM-1, though stable at room temperature, is best stored desiccated below 0 °C.
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- 抗原
- ESM1 (Endothelial Cell-Specific Molecule 1 (ESM1))
- 别名
- Endocan/ESM-1 (ESM1 产品)
- 别名
- ESM1 Protein, zgc:153027 Protein, 0610042H23Rik Protein, AV004503 Protein, ESM-1 Protein, Pg25 Protein, endocan Protein, endothelial cell specific molecule 1 Protein, endothelial cell-specific molecule 1 Protein, ESM1 Protein, esm1 Protein, Esm1 Protein
- 背景
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Endocan, also known as endothelial cell-specific molecule1 (ESM1), is a secreted cysteine-rich dermatan sulfate (DS) proteoglycan primarily expressed by endothelial cells within the vascular capillary network in kidney and in the alveolar walls of the lung. Endocan expression has also been detected in different epithelia and in adipocytes. The expression of endocan is up-regulated by TNFα, IL1β or lipopolysaccharide and down-regulated by IFNγ. The human Endocan gene encodes a 184 amino acid (aa) residues precursor protein with a 19 aa hydrophobic signal peptide and a 165 aa mature region with 18 Cysteine residues. The DS chain is covalently attached to serine 137. Endocan has been shown to bind CD11a/CD18 integrin (also known as lymphocyte function-associated antigen1, LFA1) on human lymphocytes, monocytes and Jurkat cells, inhibiting its binding to ICAM1 and reducing LFA1mediated leukocyte activation. Endocan binds via its DS chain to hepatocyte growth factor (HGF) to enhance HGF mitogenic activity. Genetically engineered cells overexpressing Endocan has been shown to induce tumor formation, suggesting that Endocan may be involved in the pathophysiology of tumor growth in vivo. Circulating Endocan can be detected in the serum from healthy subjects. In patients with lung cancer or acute and severe sepsis, elevated Endocan concentrations have been reported.
Synonyms: Esm1, ESM-1, AV004503, 0610042H23Rik, endothelial cell-specific molecule 1 - 分子量
- 19.07 kDa
- NCBI登录号
- NM_023612, NP_076101
- UniProt
- Q9QYY7
- 途径
- Growth Factor Binding
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