Flagellin Protein (FliC)
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- 抗原 See all Flagellin (FliC) 蛋白
- Flagellin (FliC)
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 人, 小鼠
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资源
- Salmonella typhimurium
- 应用范围
- SDS-PAGE (SDS)
- 特异性
- Binds to human and mouse TLR5 (Toll-like receptor 5).
- 交叉反应
- 人, 小鼠
- 纯度
- >90 % (SDS-PAGE)
- 内毒素水平
- <0.1EU/μg purified protein (LAL test, Lonza).
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- Discover our top product FliC 蛋白
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Flagellin (FliC) (AA 2-498) protein (His tag)
FliC 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE ELISA, WB
Flagellin (FliC) proteinFliC 宿主: Borrelia burgdorferi 宿主: 大肠杆菌（E. Coli） Recombinant ELISA, WB
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 说明
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Activation of TLR5 in human epithelial cell assays based on NF-kappaB luciferase fusions, on expression of IL-8 (CXCL8), CCL20, inducible nitric oxide synthase, beta-defensin 2 and matrilysin (MMP-7). Maturation of dendritic cells in in vitro and in vivo assays. Adjuvant activity on foreign antigens delivered by subcutaneous and intranasal routes in mice. TLR5 can be stimulated in vitro by Flagellin at a concentration of 5-50ng /ml and in vivo at a starting concentration of 0.1-1μg /mouse.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Reconstitute with 100 μL sterile water.
- 浓度
- Lot specific
- 缓冲液
- Lyophilized. Contains PBS.
- 储存条件
- 4 °C,-20 °C
- 储存方法
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Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 6 months after receipt when stored at -20°C. - 有效期
- 6 months
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- 抗原
- Flagellin (FliC)
- 别名
- Flagellin (FliC 产品)
- 别名
- hag Protein, flaG Protein, flagellin Protein, flagellin (flic) Protein, flagellin E Protein, flagellin protein flic Protein, fliC Protein, FliC Protein, fliC+F2048 Protein, CJJ81176_1339 Protein, C8J_1256 Protein
- 物质类
- Tag
- 背景
- Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. It activates the innate immune system through the receptor Toll-like Receptor 5 (TLR5) and the intracellular protein NLRC4 (NLR family CARD domain-containing protein 4).
- UniProt
- P06179
- 途径
- Inflammasome
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