ANGPTL4 Protein (AA 1-410) (DYKDDDDK Tag)
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- 抗原 See all ANGPTL4 蛋白
- ANGPTL4 (Angiopoietin-Like 4 (ANGPTL4))
- 蛋白类型
- Recombinant
- 生物活性
- Active
- 产品特性
- AA 1-410
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宿主
- 小鼠
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资源
- COS-7 Cells
- 标记
- This ANGPTL4 protein is labelled with DYKDDDDK Tag.
- 应用范围
- SDS-PAGE (SDS)
- 交叉反应
- 小鼠
- 产品特性
- Mouse ANGPTL4 (aa 1-410) is fused at the C-terminus to a FLAG®-tag.
- 纯度
- >90 % (SDS-PAGE)
- 过滤
- 0.2 μm filtered
- 内毒素水平
- <0.1EU/μg purified protein (LAL test, Lonza).
- Top Product
- Discover our top product ANGPTL4 蛋白
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Angiopoietin-Like 4 (ANGPTL4) (AA 166-406) protein (His tag)
ANGPTL4 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Angiopoietin-Like 4 (ANGPTL4) (AA 164-406) protein (His tag)ANGPTL4 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Angiopoietin-Like 4 (ANGPTL4) (AA 26-406) protein (GST tag)ANGPTL4 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Angiopoietin-Like 4 (ANGPTL4) (AA 168-410) protein (His tag)ANGPTL4 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Angiopoietin-Like 4 (ANGPTL4) protein (Fc Tag)ANGPTL4 宿主: 小鼠 宿主: 人细胞 Recombinant > 95 % as determined by SDS-PAGE
Angiopoietin-Like 4 (ANGPTL4) (AA 26-130) protein (GST tag)ANGPTL4 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Angiopoietin-Like 4 (ANGPTL4) (AA 26-406) protein (His tag)Crystallography grade ANGPTL4 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Angiopoietin-Like 4 (ANGPTL4) (AA 24-410) protein (His tag)Crystallography grade ANGPTL4 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 说明
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Activates ERK phosphorylation in THP-1 cells.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- Lot specific
- 缓冲液
- 0.2μm-filtered solution in PBS.
- 储存条件
- 4 °C,-20 °C
- 储存方法
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Short Term Storage: +4°C
Long Term Storage: -20°C
Working aliquots are stable for up to 3 months when stored at -20°C. - 有效期
- 3 months
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- 抗原
- ANGPTL4 (Angiopoietin-Like 4 (ANGPTL4))
- 别名
- ANGPTL4 (ANGPTL4 产品)
- 别名
- ANGPTL2 Protein, ARP4 Protein, FIAF Protein, HFARP Protein, NL2 Protein, PGAR Protein, pp1158 Protein, Arp4 Protein, Bk89 Protein, Fiaf Protein, Hfarp Protein, Ng27 Protein, Pgar Protein, Pgarg Protein, Pp1158 Protein, ANGPTL4 Protein, fiaf Protein, im:7144703 Protein, si:rp71-39b20.7 Protein, angiopoietin like 4 Protein, angiopoietin-like 4 Protein, ANGPTL4 Protein, Angptl4 Protein, angptl4 Protein
- 背景
- ANGPTL4 (Angiopoietin-like protein 4) mainly expressed in endothelial cells (hypoxia-induced). Regulates angiogenesis and modulates tumorigenesis and directly regulates lipid, glucose, and energy metabolism. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. ANGPTL4 is a protein consisting of an N-terminal coiled-coil domain and a C-terminal fibrinogen-like domain (FLD). Both domains have distinct biological functions. The coiled-coil domain is responsible for the inhibitory effects on lipoprotein lipase (LPL) converting the active form of LPL into an inactive form, and the FLD domain mediates its antiangiogenic functions. The coiled coil and the FLD domains are separated by a short linker that can be cleaved after secretion. ANGPTL4 appears on the cell surface as the full-length form, where it can be released by heparin treatment. ANGPTL4 protein is then proteolytically cleaved by proprotein convertases (PCs), including furin, PC5/6, paired basic amino acid-cleaving enzyme 4, and PC7.
- 分子量
- ~50kDa (SDS-PAGE)
- UniProt
- Q9Z1P8
- 途径
- Regulation of Lipid Metabolism by PPARalpha
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