VNN1 Protein (AA 22-490) (His tag)
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- 抗原 See all VNN1 蛋白
- VNN1 (Vanin 1 (VNN1))
- 蛋白类型
- Recombinant
- 产品特性
- AA 22-490
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宿主
- 人
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资源
- 人细胞
- 标记
- This VNN1 protein is labelled with His tag.
- 原理
- Recombinant Human Vascular Non-Inflammatory Molecule 1/Vanin-1/VNN1 (C-6His)
- 序列
- QDTFTAAVYE HAAILPNATL TPVSREEALA LMNRNLDILE GAITSAADQG AHIIVTPEDA IYGWNFNRDS LYPYLEDIPN PEVNWIPCNN RNRFGQTPVQ ERLSCLAKNN SIYVVANIGD KKPCDTSDPQ CPPDGRYQYN TDVVFDSQGK LVARYHKQNL FMGENQFNVP KEPEIVTFNT TFGSFGIFTC FDILFHDPAV TLVKDFHVDT IVFPTAWMNV LPHLSAVEFH SAWAMGMRVN FLASNIHYPS KKMTGSGIYA PNSSRAFHYD MKTEEGKLLL SQLDSHPSHS AVVNWTSYAS SIEALSSGNK EFKGTVFFDE FTFVKLTGVA GNYTVCQKDL CCHLSYKMSE NIPNEVYALG AFDGLHTVEG RYYLQICTLL KCKTTNLNTC GDSAETASTR FEMFSLSGTF GTQYVFPEVL LSENQLAPGE FQVSTDGRLF SLKPTSGPVL TVTLFGRLYE KDWASNASSV DHHHHHH
- 产品特性
- Recombinant Human Vascular Non-Inflammatory Molecule 1/Vanin-1 produced by transfected human cells is a secreted protein with sequence (Gln22-Ser490) of Human VNN1 fused with a polyhistidine tag at the C-terminus.
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
- 过滤
- 0.2 μm filtered
- 内毒素水平
- Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test
- Top Product
- Discover our top product VNN1 蛋白
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Vanin 1 (VNN1) (AA 1-513) protein (GST tag)
VNN1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Vanin 1 (VNN1) (AA 298-397) protein (GST tag)VNN1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Vanin 1 (VNN1) protein (Fc Tag)VNN1 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 96 % as determined by SDS-PAGE
Vanin 1 (VNN1) (AA 22-491) protein (His tag)Crystallography grade VNN1 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
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It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles. - 缓冲液
- Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.2.
- 注意事项
- Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
- 储存条件
- 4 °C/-20 °C/-80 °C
- 储存方法
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Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months. - 有效期
- 3 months
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- 抗原
- VNN1 (Vanin 1 (VNN1))
- 别名
- vanin-1 (VNN1 产品)
- 别名
- HDLCQ8 Protein, Tiff66 Protein, V-1 Protein, hdlcq8 Protein, tiff66 Protein, vnn1.1 Protein, vanin-1 Protein, vanin 1 Protein, pantetheinase Protein, VNN1 Protein, Vnn1 Protein, vnn1 Protein, LOC100217969 Protein
- Sub Type
- Fusionprotein
- 背景
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Vanin-1 is a cell membrane protein which contains one CN hydrolase domain and belongs to the CN hydrolase family and BTD/VNN subfamily. Vanin-1 is also a member of the Vanin family of proteins, which share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. Vanin-1 is widely expressed with higher expression in spleen, kidney and blood and overexpressed in lesional psoriatic skin. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. Vanin-1 is an epithelial pantetheinase that provides cysteamine to tissue and regulates response to stress. Vanin-1 is expressed by enterocytes, and its absence limits intestinal epithelial cell production of proinflammatory signals. Vanin-1 regulates late adhesion steps of thymus homing under physiological, noninflammatory conditions. The early impact of vanin-1 deficiency on tumor induction was directly correlated to the amount of inflammation and subsequent epithelial proliferation rather than cell death rate. Vanin-1 molecule was shown to be involved in the control of thymus reconstitution following sub-lethal irradiation.ReferencesC spry, et al. Pantothenamides are potent, on-target inhibitors of Plasmodium falciparum growth when serum pantetheinase is inactivated.PMID: 23405100 [PubMed - in process] PMCID: PMC3566143http://www.ncbi.nlm.nih.gov/pubmed/23405100
Alternative Names: Pantetheinase, Pantetheine Hydrolase, Tiff66, Vascular Non-Inflammatory Molecule 1, Vanin-1, VNN1 - 分子量
- 53.27 kDa
- UniProt
- O95497
- 途径
- Negative Regulation of intrinsic apoptotic Signaling
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