PRKAA2 抗体
(Protein Kinase, AMP-Activated, alpha 2 Catalytic Subunit (PRKAA2))
The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. [provided by RefSeq, Jul 2008].
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Latest Publications for our PRKAA2 抗体
: "Metformin protects against PM2.5-induced lung injury and cardiac dysfunction independent of AMP-activated protein kinase α2." in: Redox biology, Vol. 28, pp. 101345, (2020) (PubMed).: "The evidence of metabolic-improving effect of metformin in Ay/a mice with genetically-induced melanocortin obesity and the contribution of hypothalamic mechanisms to this effect." in: PLoS ONE, Vol. 14, Issue 3, pp. e0213779, (2019) (PubMed).
: "Alternative polyadenylation drives genome-to-phenome information detours in the AMPKα1 and AMPKα2 knockout mice." in: Scientific reports, Vol. 8, Issue 1, pp. 6462, (2018) (PubMed).
: "Metformin ameliorates hepatic steatosis and improves the induction of autophagy in HFD‑induced obese mice." in: Molecular medicine reports, Vol. 16, Issue 1, pp. 680-686, (2017) (PubMed).
: "AMP-activated protein kinase stimulates Warburg-like glycolysis and activation of satellite cells during muscle regeneration." in: The Journal of biological chemistry, Vol. 290, Issue 44, pp. 26445-56, (2015) (PubMed).
: "High CO2 levels cause skeletal muscle atrophy via AMP-activated kinase (AMPK), FoxO3a protein, and muscle-specific Ring finger protein 1 (MuRF1)." in: The Journal of biological chemistry, Vol. 290, Issue 14, pp. 9183-94, (2015) (PubMed).
: "Functional dissection of lysine deacetylases reveals that HDAC1 and p300 regulate AMPK." in: Nature, Vol. 482, Issue 7384, pp. 251-5, (2012) (PubMed).
: "Reduction of AMP-activated protein kinase alpha2 increases endoplasmic reticulum stress and atherosclerosis in vivo." in: Circulation, Vol. 121, Issue 6, pp. 792-803, (2010) (PubMed).
: "Alpha1-AMP-activated protein kinase regulates hypoxia-induced Na,K-ATPase endocytosis via direct phosphorylation of protein kinase C zeta." in: Molecular and cellular biology, Vol. 29, Issue 13, pp. 3455-64, (2009) (PubMed).
: "Stimulation of the AMP-activated protein kinase leads to activation of eukaryotic elongation factor 2 kinase and to its phosphorylation at a novel site, serine 398." in: The Journal of biological chemistry, Vol. 279, Issue 13, pp. 12220-31, (2004) (PubMed).
Aliases for PRKAA2 抗体
protein kinase AMP-activated catalytic subunit alpha 2 (PRKAA2) 抗体protein kinase AMP-activated catalytic subunit alpha 2 (Prkaa2) 抗体
protein kinase, AMP-activated, alpha 2 catalytic subunit (Prkaa2) 抗体
protein kinase, AMP-activated, alpha 2 catalytic subunit S homeolog (prkaa2.S) 抗体
protein kinase, AMP-activated, alpha 2 catalytic subunit (prkaa2) 抗体
2310008I11Rik 抗体
A830082D05 抗体
AMPK 抗体
Ampk 抗体
ampk 抗体
AMPK2 抗体
ampk2 抗体
AMPKa2 抗体
Ampka2 抗体
AMPKA2 抗体
AMPKalpha2 抗体
PRKAA 抗体
prkaa 抗体
prkaa1 抗体
PRKAA2 抗体
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