Presenilin 2 抗体
(Presenilin 2 (Alzheimer Disease 4) (PSEN2))
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. [provided by RefSeq, Jul 2008].
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Carrier-free
PSEN2
适用: 人, 大鼠, 小鼠
WB, IHC, IF, FACS, ICC
宿主: 兔
Polyclonal
unconjugated
Latest Publications for our Presenilin 2 抗体
: "Novel MITF targets identified using a two-step DNA microarray strategy." in: Pigment cell & melanoma research, Vol. 21, Issue 6, pp. 665-76, (2008) (PubMed).
: "(TA)n UGT 1A1 promoter polymorphism: a crucial factor in the pathophysiology of jaundice in G-6-PD deficient neonates." in: Pediatric research, Vol. 61, Issue 6, pp. 727-31, (2007) (PubMed).
: "A novel mutation in the PSEN2 gene (T430M) associated with variable expression in a family with early-onset Alzheimer disease." in: Archives of neurology, Vol. 60, Issue 8, pp. 1149-51, (2003) (PubMed).
: "Absence of association between Alzheimer disease and the regulatory region polymorphism of the PS2 gene in an Italian population." in: Neuroscience letters, Vol. 343, Issue 3, pp. 210-2, (2003) (PubMed).
: "In vitro characterization of the presenilin-dependent gamma-secretase complex using a novel affinity ligand." in: Biochemistry, Vol. 42, Issue 27, pp. 8133-42, (2003) (PubMed).
: "Endoplasmic reticulum stress-inducible protein, Herp, enhances presenilin-mediated generation of amyloid beta-protein." in: The Journal of biological chemistry, Vol. 277, Issue 15, pp. 12915-20, (2002) (PubMed).
: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ..." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, (2002) (PubMed).
: "High prevalence of pathogenic mutations in patients with early-onset dementia detected by sequence analyses of four different genes." in: American journal of human genetics, Vol. 66, Issue 1, pp. 110-7, (2000) (PubMed).
: "Genomic structure and expression of STM2, the chromosome 1 familial Alzheimer disease gene." in: Genomics, Vol. 34, Issue 2, pp. 198-204, (1997) (PubMed).
: "Identification and expression analysis of a potential familial Alzheimer disease gene on chromosome 1 related to AD3." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, Issue 26, pp. 12180-4, (1996) (PubMed).
: "(TA)n UGT 1A1 promoter polymorphism: a crucial factor in the pathophysiology of jaundice in G-6-PD deficient neonates." in: Pediatric research, Vol. 61, Issue 6, pp. 727-31, (2007) (PubMed).
: "A novel mutation in the PSEN2 gene (T430M) associated with variable expression in a family with early-onset Alzheimer disease." in: Archives of neurology, Vol. 60, Issue 8, pp. 1149-51, (2003) (PubMed).
: "Absence of association between Alzheimer disease and the regulatory region polymorphism of the PS2 gene in an Italian population." in: Neuroscience letters, Vol. 343, Issue 3, pp. 210-2, (2003) (PubMed).
: "In vitro characterization of the presenilin-dependent gamma-secretase complex using a novel affinity ligand." in: Biochemistry, Vol. 42, Issue 27, pp. 8133-42, (2003) (PubMed).
: "Endoplasmic reticulum stress-inducible protein, Herp, enhances presenilin-mediated generation of amyloid beta-protein." in: The Journal of biological chemistry, Vol. 277, Issue 15, pp. 12915-20, (2002) (PubMed).
: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ..." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, (2002) (PubMed).
: "High prevalence of pathogenic mutations in patients with early-onset dementia detected by sequence analyses of four different genes." in: American journal of human genetics, Vol. 66, Issue 1, pp. 110-7, (2000) (PubMed).
: "Genomic structure and expression of STM2, the chromosome 1 familial Alzheimer disease gene." in: Genomics, Vol. 34, Issue 2, pp. 198-204, (1997) (PubMed).
: "Identification and expression analysis of a potential familial Alzheimer disease gene on chromosome 1 related to AD3." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, Issue 26, pp. 12180-4, (1996) (PubMed).
Aliases for Presenilin 2 抗体
presenilin 2 (PSEN2) 抗体presenilin 2 (Psen2) 抗体
presenilin 2 (psen2) 抗体
presenilin 2 S homeolog (psen2.S) 抗体
presenilin 2 (Alzheimer disease 4) (PSEN2) 抗体
trefoil factor 1 (Tff1) 抗体
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pre2 抗体
PS-2 抗体
PS2 抗体
ps2 抗体
Ps2 抗体
PSEN2 抗体
Psnl2 抗体
PSNL2 抗体
STM2 抗体
stm2 抗体
zf-PS2 抗体
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