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NLRP3 蛋白

(NLR Family, Pyrin Domain Containing 3 (NLRP3))
This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data\; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid. [provided by RefSeq, Oct 2008].
NLRP3 Protein (AA 1-1036) (GST tag) NLRP3 Protein (AA 1-1036) (GST tag) NLRP3 Protein (AA 1-1036) (GST tag) (ABIN1312675)

NLRP3 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA

NLRP3 Protein (AA 5-218) (His-IF2DI Tag) NLRP3 Protein (AA 5-218) (His-IF2DI Tag) NLRP3 Protein (AA 5-218) (His-IF2DI Tag) (ABIN7124184)

NLRP3 宿主: 人 宿主: 大肠杆菌(E. Coli) Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA

NLRP3 Protein (AA 1-100) (GST tag) NLRP3 Protein (AA 1-100) (GST tag) NLRP3 Protein (AA 1-100) (GST tag) (ABIN1312677)

NLRP3 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA

NLRP3 蛋白 by Origin

Find NLRP3 蛋白 for a variety of species such as anti-Human NLRP3, anti-Mouse NLRP3. The species listed below are among those available. Click on a link to go to the corresponding products.

NLRP3 蛋白 by Source

Here you will find NLRP3 蛋白 proteins organized by several key sources. By clicking on a link, you can access the products. For additional sources, please use our search function.

NLRP3 蛋白 by 蛋白类型

Here you can find NLRP3 蛋白 proteins categorized by available protein types. Additional protein types can be located using our search function.

NLRP3 蛋白 by 应用范围

Find NLRP3 蛋白 validated for a specific application such as WB, ELISA, SDS, AP. Some of the available applications are listed below. Click on a link to go to the corresponding products.

Popular NLRP3 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (5)
  • (1)
Cat. No. ABIN1312675
Quantity 2 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7124184
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1312677
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN6964301
Quantity 100 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7417258
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7423546
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3094146
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3136668
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our NLRP3 蛋白

Shi, Wang, Li, Zhan, Tang, Fina, Su, Pratt, Bu, Hildebrand, Lyon, Scott, Quan, Sun, Russell, Arnett, Jurek, Chen, Kravchenko, Mathison, Moresco, Monson, Ulevitch, Beutler: "NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component." in: Nature immunology, Vol. 17, Issue 3, pp. 250-8, (2016) (PubMed).

He, Varadarajan, Muñoz-Planillo, Burberry, Nakamura, Núñez: "3,4-methylenedioxy-?-nitrostyrene inhibits NLRP3 inflammasome activation by blocking assembly of the inflammasome." in: The Journal of biological chemistry, Vol. 289, Issue 2, pp. 1142-50, (2014) (PubMed).

Cocco, Garella, Di Stilo, Borretto, Stevanato, Giorgis, Marini, Fantozzi, Miglio, Bertinaria: "Electrophilic warhead-based design of compounds preventing NLRP3 inflammasome-dependent pyroptosis." in: Journal of medicinal chemistry, Vol. 57, Issue 24, pp. 10366-82, (2014) (PubMed).

Bruchard, Mignot, Derangère, Chalmin, Chevriaux, Végran, Boireau, Simon, Ryffel, Connat, Kanellopoulos, Martin, Rébé, Apetoh, Ghiringhelli: "Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth." in: Nature medicine, Vol. 19, Issue 1, pp. 57-64, (2013) (PubMed).

Lu, Nakamura, Inouye, Li, Tang, Lundbäck, Valdes-Ferrer, Olofsson, Kalb, Roth, Zou, Erlandsson-Harris, Yang, Ting, Wang, Andersson, Antoine, Chavan, Hotamisligil, Tracey: "Novel role of PKR in inflammasome activation and HMGB1 release." in: Nature, Vol. 488, Issue 7413, pp. 670-4, (2012) (PubMed).

Aliases for NLRP3 蛋白

NLR family pyrin domain containing-like (NLRPL) 蛋白
NLR family pyrin domain containing 3 (NLRP3) 蛋白
NLR family, pyrin domain containing 3 L homeolog (nlrp3.L) 蛋白
NLR family, pyrin domain containing 3 (Nlrp3) 蛋白
agtavprl 蛋白
AGTAVPRL 蛋白
AII 蛋白
AII/AVP 蛋白
avp 蛋白
AVP 蛋白
C1orf7 蛋白
CIAS1 蛋白
cias1 蛋白
Cias1 蛋白
CLR1.1 蛋白
FCAS 蛋白
FCU 蛋白
Mmig1 蛋白
MWS 蛋白
Nalp3 蛋白
nalp3 蛋白
NALP3 蛋白
pypaf1 蛋白
PYPAF1 蛋白
Pypaf1 蛋白
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