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dual PI3K (显示 PIK3CA ELISA试剂盒) and mTOR inhibitor, BEZ235 with the HDAC (显示 HDAC3 ELISA试剂盒) inhibitor Trichostatin A (TSA (显示 PRDX2 ELISA试剂盒)) significantly increased anti-tumor activities compared with BEZ235 and TSA (显示 PRDX2 ELISA试剂盒) alone, suggesting a combination treatment for non-small-cell lung cancer (NSCLC).
cellular vacuolization, represents a condition of profound lysosome stress, and cells sense and respond to this stress by facilitating mTOR-dependent TFEB nucleus translocation in an effort to restore lysosome homeostasis.
Dual PI3K (显示 PIK3CA ELISA试剂盒)/mTOR inhibition represents an effective therapeutic strategy in uterine leiomyosarcoma, and p-S6(S240) expression is a potential predictive biomarker for response to treatment.
PI3K (显示 PIK3CA ELISA试剂盒)/mTOR inhibitors with weak affinities for ABC (显示 ABCB6 ELISA试剂盒) transporters can achieve target inhibition in brain (tumors), but have modest single-agent efficacy and combinations with (BBB (显示 ALMS1 ELISA试剂盒) penetrable) inhibitors of other activated pathways may be required
Studies indicate that understanding mTOR network circuitry will provide insight into its deregulation in diabetes, cancer, and cardiovascular disease, but modeling in silico to elucidate how insulin (显示 INS ELISA试剂盒) activates mTORC2 (显示 CRTC2 ELISA试剂盒) remains poorly defined.
Studied the prognostic value of HER2 (显示 ERBB2 ELISA试剂盒)-HER3 (显示 ERBB3 ELISA试剂盒) and p-mTOR expression in gastric cancer tissue. HER3 (显示 ERBB3 ELISA试剂盒) overexpression was associated with depth of invasion; HER2 (显示 ERBB2 ELISA试剂盒)-HER3 (显示 ERBB3 ELISA试剂盒) overexpression corresponded to gradually shortened 5-year overall survival; p-mTOR overexpression was found to be associated with patient age, tumor location, depth of invasion.
PI3K (显示 PIK3CA ELISA试剂盒)-PTEN upregulated-mTORC1 and mTORC2 (显示 CRTC2 ELISA试剂盒) complex plays a critical role in controlling BMAL1 (显示 ARNTL ELISA试剂盒), establishing a connection between PI3K (显示 PIK3CA ELISA试剂盒) signaling and the regulation of circadian rhythm, ultimately resulting in deregulated BMAL1 (显示 ARNTL ELISA试剂盒) in tumor cells with disrupted PI3K (显示 PIK3CA ELISA试剂盒) signaling
Multiple RRAGC (显示 RRAGC ELISA试剂盒) mutations demonstrated elevated MTOR activation.
MLN0128 selectively targeted and functionally inhibited acute myeloid leukemia (显示 BCL11A ELISA试剂盒) (AML (显示 RUNX1 ELISA试剂盒)) stem/progenitor cells with high AKT (显示 AKT1 ELISA试剂盒)/mTOR kinase signaling activity.
Combined treatment with gamma-irradiation (gammaIR) and a dual PI3K (显示 PIK3CA ELISA试剂盒)/mTOR inhibitor causes loss of stemness and of FoxO1 (显示 FOXO1 ELISA试剂盒)/3 proteins in p53 (显示 TP53 ELISA试剂盒)-proficient glioblastoma multiforme stem cells (GBM-SCs (显示 TWIST1 ELISA试剂盒)).
In mTOR gene deletion, the astrocyte population exhibited a lower seizure frequency compared with controls in an animal model of temporal lobe epilepsy.
UVB-irradiated or aged mice skin revealed that mTORC2 (显示 CRTC2 ELISA试剂盒) activity was significantly upregulated which in turn increased Akt (显示 AKT1 ELISA试剂盒) activation and Akt (显示 AKT1 ELISA试剂盒)-dependent IkappaB kinase alpha (显示 CHUK ELISA试剂盒) (IKKalpha (显示 CHUK ELISA试剂盒)) phosphorylation, and The increased mTORC2 (显示 CRTC2 ELISA试剂盒) signaling pathway during skin aging were associated to NF-kappaB (显示 NFKB1 ELISA试剂盒) activation.
Mitogen-activated protein kinase (显示 MAPK1 ELISA试剂盒) interacting protein (显示 CIB1 ELISA试剂盒) kinases (Mnks) control translation by phosphorylation of eIF4E (显示 EIF4E ELISA试剂盒), whereas the mTOR kinase phosphorylates/de-activates the eIF4E (显示 EIF4E ELISA试剂盒) inhibitor, 4E-BP1 (显示 EIF4EBP1 ELISA试剂盒), to release translational repression.
Cul-1 (显示 CUL1 ELISA试剂盒) deneddylation led to Deptor (显示 DEPTOR ELISA试剂盒) accumulation and subsequent mTOR inactivation, which had an inhibitory effect on dendritic cells in mouse model of inflammatory bowel disease.
Trehalose may rescue against insulin (显示 INS ELISA试剂盒) resistance-induced myocardial contractile defect and apoptosis, via autophagy associated with dephosphorylation of p38 MAPK (显示 MAPK14 ELISA试剂盒) and Foxo1 (显示 FOXO1 ELISA试剂盒) without affecting phosphorylation of Akt (显示 AKT1 ELISA试剂盒).
These findings highlight the importance of autophagy as therapeutic target and suggest that elucidating connections between protein unfolding and mTOR-dependent or mTOR-independent hypertrophic responses is likely to reveal specific therapeutic windows for the treatment of muscle wasting disorders
Data show that activated protein C (显示 PROC ELISA试剂盒) (aPC (显示 APC ELISA试剂盒)) inhibited Nlrp3 (显示 NLRP3 ELISA试剂盒) inflammasome activation via mammalian target of rapamycin complex 1 (mTORC1) signaling.
Collectively, our findings indicate that miR (显示 MLXIP ELISA试剂盒)-140 exerts anti-OS efficacy by targeting immune checkpoint molecule PD-L1 (显示 CD274 ELISA试剂盒) and can be developed as a novel immunotherapeutic agent for the treatment of OS.
Thus, the various regulatory elements that impinge upstream of mTORC1 activation pathways are differentially required for HSC (显示 FUT1 ELISA试剂盒) homeostasis in vivo.
Loganin is capable of increas-ing the SMN (显示 STMN1 ELISA试剂盒) protein level under SMN (显示 STMN1 ELISA试剂盒)-deficient conditions both inin vitro and in vivo models of spinal muscular atrophy via Akt (显示 AKT1 ELISA试剂盒)/mTOR pathway.
This study reveals the dramatic rescue effects of L-leucine stimulation of mTORC1 in RBS (显示 ESCO2 ELISA试剂盒) cells and supports that normal gene expression and translation requires ESCO2 (显示 ESCO2 ELISA试剂盒) function.
By inhibiting mTOR signaling via Fbxw7 (显示 FBXW7 ELISA试剂盒), the amount of myelination during development is reduced.
Apc mutations activate mechanistic target of rapamycin complex 1 in mice and zebrafish
In our zebrafish model, autophagy induction does not depend on inhibition of the Tor pathway or activation of Tp53 (显示 TP53 ELISA试剂盒).
TOR signaling is a common pathological pathway that can be leveraged for therapeutic benefits in cardiomyopathies of different origins.
in addition to regulating cell growth and proliferation, TOR signaling controls the developmental program guiding epithelial morphogenesis in the intestine
The immunoprecipitation results also showed that high AA concentrations significantly increased the interaction of mTOR and PPARg (显示 PPARG ELISA试剂盒). In summary, PPARg (显示 PPARG ELISA试剂盒) plays an important role in the regulation of IGF-1 (显示 IGF1 ELISA试剂盒) secretion and gene expression in response to dietary protein.
These results indicate glycine enhances muscle protein mass under an inflammatory condition. The beneficial roles of glycine on the muscle are closely associated with maintaining Akt (显示 AKT1 ELISA试剂盒)-mTOR-FOXO1 (显示 FOXO1 ELISA试剂盒) signaling and suppressing the activation of TLR4 (显示 TLR4 ELISA试剂盒) and/or NOD2 (显示 NOD2 ELISA试剂盒) signaling pathways.
Data show that the amount of proteins related to mechanistic target of rapamycin (mTOR) signaling pathways decreased along crypt-villus axis (CVA).
AMPK (显示 PRKAA1 ELISA试剂盒)-mTOR-autophagy signaling is altered by intrauterine growth restriction in newborn piglets.
Uroguanylin (显示 GUCA2B ELISA试剂盒) modulates (Na++K+)ATPase (显示 ATP1A1 ELISA试剂盒) in a proximal tubule cells via cGMP/protein kinase (显示 CDK7 ELISA试剂盒) G, cAMP/protein kinase A, and mTOR pathways.
mTOR is involved in 17beta-estradiol-induced, cultured immature boar Sertoli cell proliferation via regulating the expression of SKP2, CCND1 (显示 CCND1 ELISA试剂盒), and CCNE1 (显示 CCNE1 ELISA试剂盒).
L-Glutamine enhances enterocyte growth via activation of the mTOR.
Arg, Leu, and Gln act coordinately to stimulate proliferation of pTr cells through activation of the MTOR-RPS6K-RPS6 (显示 RPS6 ELISA试剂盒)-EIF4EBP1 (显示 EIF4EBP1 ELISA试剂盒) signal transduction pathway.
Data indicate that the expression of MAP1LC3A (显示 MAP1LC3A ELISA试剂盒), B and autophagy-associated genes (ATG5 (显示 ATG5 ELISA试剂盒), mTOR, Beclin-1 (显示 BECN1 ELISA试剂盒)) was increased in normal pigs, while decreased in miniature pigs.
Biochemical, cellular, and molecular data suggest that L-arginine (显示 GATM ELISA试剂盒) stimulates mTOR biosynthesis, mTOR signaling, and overall protein biosynthesis/turnover in placental/trophoblast and blastocyst/ectoderm cells thereby enhancing cell proliferation.
AnxA2 (显示 ANXA2 ELISA试剂盒) functions as a critical regulator for amino acid or hormone-induced milk synthesis and mammary gland epithelial cell proliferation via the PI3K-mTOR-SREBP-1c (显示 SREBF1 ELISA试剂盒)/Cyclin D1 (显示 CCND1 ELISA试剂盒) signaling pathway.
These findings suggest that mTOR is involved in the control of the expression of multiple genes in cattle, which may be triggered by the luteinizing hormone surge.
14-3-3gamma (显示 YWHAG ELISA试剂盒) affects mTOR protein pathway and regulates lactogenesis in dairy cow mammary epithelial cells.
Methionine promoted casein synthesis, and this may be mediated by enhanced intracellular substrate availability and by activating JAK2 (显示 JAK2 ELISA试剂盒)-STAT5 (显示 STAT5A ELISA试剂盒) and mTOR signaling pathways.
Insulin (显示 INS ELISA试剂盒)-induced activation of phosphoinositide 3-kinase~mTOR pathway up-regulates tau protein via acceleration of protein synthesis in adrenal chromaffin cells, promoting neurite-like process outgrowth.
IGF-I (显示 IGF1 ELISA试剂盒) down-regulated functional IGF-I receptor (显示 IGF1R ELISA试剂盒) via GSK-3beta (显示 GSK3b ELISA试剂盒) inhibition and mTOR activation; constitutive activity of GSK-3beta (显示 GSK3b ELISA试剂盒) maintained IGF-I receptor (显示 IGF1R ELISA试剂盒) level in nonstimulated cells.
stimulation of mammary protein synthesis by amino acids and its enhancement by a combination of the lactogenic hormones hydrocortisone, insulin (显示 INS ELISA试剂盒), and prolactin (显示 PRL ELISA试剂盒) were associated with increased phosphorylation of the mTOR substrates
data demonstrate that hypoxia-induced adventitial fibroblast proliferation requires activation and interaction of PI3K, Akt (显示 AKT1 ELISA试剂盒), mTOR, p70S6K (显示 RPS6KB1 ELISA试剂盒), and ERK1/2 (显示 MAPK1/3 ELISA试剂盒).
prostaglandin F2alpha phosphorylates TSC2 (显示 TSC2 ELISA试剂盒) and activates mTOR and ribosomal protein S6 (显示 RPS6 ELISA试剂盒) kinase (显示 RPS6KB1 ELISA试剂盒) signaling in an AKT (显示 AKT1 ELISA试剂盒)-independent manner
mTOR links IGF-I (显示 IGF1 ELISA试剂盒) and EGF (显示 EGF ELISA试剂盒) signaling in inhibiting the autophagy pathways.
The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene.
FK506 binding protein 12-rapamycin associated protein 1
, FK506 binding protein 12-rapamycin associated protein 2
, FK506-binding protein 12-rapamycin complex-associated protein 1
, FKBP-rapamycin associated protein
, FKBP12-rapamycin complex-associated protein 1
, mammalian target of rapamycin
, rapamycin and FKBP12 target 1
, rapamycin associated protein FRAP2
, rapamycin target protein 1
, serine/threonine-protein kinase mTOR
, FKBP-rapamycin associated protein (FRAP)
, FKBP-rapamycin-associated protein FRAP
, FKBP12-rapamycin complex-associated protein
, angiopoietin-like factor CDT6
, rapamycin and FKBP12 target-1 protein
, target of rapamycin