PHLDA3 抗体
(Pleckstrin Homology-Like Domain, Family A, Member 3 (PHLDA3))
p53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its directs transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1. May acts as a tumor suppressor (By similarity).
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23 results :
PHLDA3
适用: 人, 小鼠, 大鼠
ELISA, IHC, WB
宿主: 兔
Polyclonal
unconjugated
1 image
PHLDA3
适用: 人, 小鼠, 大鼠
ELISA, IHC, WB
宿主: 兔
Polyclonal
unconjugated
1 image
Latest Publications for our PHLDA3 抗体
: "PH domain-only protein PHLDA3 is a p53-regulated repressor of Akt." in: Cell, Vol. 136, Issue 3, pp. 535-50, (2009) (PubMed).: "A novel pleckstrin homology-related gene family defined by Ipl/Tssc3, TDAG51, and Tih1: tissue-specific expression, chromosomal location, and parental imprinting." in: Mammalian genome : official journal of the International Mammalian Genome Society, Vol. 10, Issue 12, pp. 1150-9, (2000) (PubMed).
Aliases for PHLDA3 抗体
pleckstrin homology like domain family A member 3 (PHLDA3) 抗体pleckstrin homology like domain, family A, member 3 (Phlda3) 抗体
pleckstrin homology-like domain, family A, member 3 (Phlda3) 抗体
pleckstrin homology-like domain, family A, member 3 (phlda3) 抗体
si:dz182n13.5 抗体
TIH1 抗体
Tih1 抗体
zgc:92333 抗体
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