This gene encodes a Polycomb group protein. The protein is a component of a histone H3 lysine-27 (H3K27)-specific methyltransferase complex, and functions in transcriptional repression of homeotic genes. The protein is also recruited to double-strand breaks, and reduced protein levels results in X-ray sensitivity and increased homologous recombination. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009].
Yang, Wang, Zhang, Gao, Wang, Yu, Zhang, Jiang, Hexige, Hong, Yasui, Liu, Huang, Yu: "Polycomb group protein PHF1 regulates p53-dependent cell growth arrest and apoptosis." in: The Journal of biological chemistry, Vol. 288, Issue 1, pp. 529-39, (2013) (PubMed).
Wang, Cheng, Qin, Jia: "Val97Leu mutant presenilin-1 induces tau hyperphosphorylation and spatial memory deficit in mice and the underlying mechanisms." in: Journal of neurochemistry, Vol. 121, Issue 1, pp. 135-45, (2012) (PubMed).
Hong, Jiang, Lan, Nakajima, Kanno, Koseki, Yasui: "A polycomb group protein, PHF1, is involved in the response to DNA double-strand breaks in human cell." in: Nucleic acids research, Vol. 36, Issue 9, pp. 2939-47, (2008) (PubMed).
Lazarov, Morfini, Pigino, Gadadhar, Chen, Robinson, Ho, Brady, Sisodia: "Impairments in fast axonal transport and motor neuron deficits in transgenic mice expressing familial Alzheimer's disease-linked mutant presenilin 1." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 27, Issue 26, pp. 7011-20, (2007) (PubMed).