Von Hippel-Lindau Tumor Suppressor, E3 Ubiquitin Protein Ligase (VHL) (N-Term) Peptide
VHL
适用: 人
宿主: 合成
BP, WB
-
- 抗原 See all VHL products
- VHL (Von Hippel-Lindau Tumor Suppressor, E3 Ubiquitin Protein Ligase (VHL))
- 蛋白结构域
- N-Term
- 宿主
- 人
-
资源
- 合成
- 应用范围
- Blocking Peptide (BP), Western Blotting (WB)
- 序列
- EDGGEESGAE ESGPEESGPE ELGAEEEMEA GRPRPVLRSV NSREPSQVIF
- 产品特性
- This is a synthetic peptide designed for use in combination with anti-VHL Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- 纯化方法
- Purified
-
Von Hippel-Lindau Tumor Suppressor, E3 Ubiquitin Protein Ligase (VHL) peptide
VHL 适用: 人, 大鼠, 小鼠, 犬 宿主: 合成 BP, Imm
-
- 应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
- 限制
- 仅限研究用
-
- 状态
- Lyophilized
- 溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- 浓度
- 1 mg/mL
- 缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
-
- 抗原
- VHL (Von Hippel-Lindau Tumor Suppressor, E3 Ubiquitin Protein Ligase (VHL))
- 别名
- HRCA1 Peptide, RCA1 Peptide, VHL1 Peptide, pVHL Peptide, BcDNA:RH61560 Peptide, CG13221 Peptide, DVhl Peptide, Dmel\\CG13221 Peptide, Dvhl Peptide, VHL Peptide, d-VHL Peptide, d-vhl Peptide, dVHL Peptide, dmVHL Peptide, vhl Peptide, rca1 Peptide, vhl1 Peptide, hrca1 Peptide, zgc:158722 Peptide, Vhlh Peptide, von Hippel-Lindau tumor suppressor Peptide, von Hippel-Lindau Peptide, von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase Peptide, von Hippel-Lindau disease tumor suppressor Peptide, VHL Peptide, Vhl Peptide, vhl Peptide, CpipJ_CPIJ009992 Peptide
- 背景
-
Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Alias Symbols: HRCA1, RCA1, VHL1, pVHL
Protein Interaction Partner: EPAS1,FLNA,FN1,HIF1A,HIF1A,PHF17,USP33,VBP1,CCT3,CUL2,EPAS1,FLNA,FN1,HIF1A,HIF1AN,HIF3A,HNRNPA2B1,PHF17,POLR2G,PSMC3,RBX1,RNF139,SP1,TCEB1,TCEB2,USP33,VBP1,ZNF197,APRT,ATM,ATXN2,CAB39,CCDC59,CCDC82,CCT3,CDK2,CDO1,CHMP2B,CNTF,CSTB,CSTF3,CUL2,CUL5,CYBA,DGKZ
Protein Size: 172 - 分子量
- 19 kDa
- 基因ID
- 7428
- NCBI登录号
- NM_198156, NP_937799
-
You are here:
