Transient Receptor Potential Cation Channel, Subfamily M, Member 8 (TRPM8) (N-Term) Peptide
TRPM8
适用: 人
宿主: 合成
BP, WB, IHC
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- 抗原 See all TRPM8 products
- TRPM8 (Transient Receptor Potential Cation Channel, Subfamily M, Member 8 (TRPM8))
- 蛋白结构域
- N-Term
- 宿主
- 人
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资源
- 合成
- 应用范围
- Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
- 产品特性
- This is a synthetic peptide designed for use in combination with anti-TRPM8 antibody (Catalog #: ARP35357_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- 纯化方法
- Purified
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- 应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- 浓度
- 1 mg/mL
- 缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- 抗原
- TRPM8 (Transient Receptor Potential Cation Channel, Subfamily M, Member 8 (TRPM8))
- 别名
- TRPM8 Peptide, trpp8 Peptide, ltrpc6 Peptide, trpm8b Peptide, LTRPC6 Peptide, TRPP8 Peptide, CMR1 Peptide, LTrpC-6 Peptide, Trp-p8 Peptide, transient receptor potential cation channel subfamily M member 8 Peptide, transient receptor potential cation channel subfamily M member 8b L homeolog Peptide, transient receptor potential cation channel, subfamily M, member 8 Peptide, TRPM8 Peptide, trpm8b.L Peptide, Trpm8 Peptide
- 背景
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TRPM8 is the receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. TRPM8 is activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH . TRPM8 is involved in menthol sensation. TRPM8 is permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. TRPM8 was activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonists menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing.
Alias Symbols: LTRPC6, MGC2849, TRPP8
Protein Size: 1104 - 分子量
- 128 kDa
- 基因ID
- 79054
- NCBI登录号
- NM_024080, NP_076985
- UniProt
- Q7Z2W7
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