Transient Receptor Potential Cation Channel, Subfamily M, Member 8 (TRPM8) Peptide
TRPM8
适用: 哺乳动物
宿主: 合成
BP, WB, IHC
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- 抗原 See all TRPM8 products
- TRPM8 (Transient Receptor Potential Cation Channel, Subfamily M, Member 8 (TRPM8))
- 蛋白类型
- Synthetic
- 宿主
- 哺乳动物
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资源
- 合成
- 应用范围
- Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
- 序列
- YILDNNHTHL LLVDNGCHGH PTVEAKLRNQ LEKYISERTI QDSNYGGKIP
- 产品特性
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A synthetic peptide for use as a blocking control in assays to test for specificity of TRPM8 antibody,
Alternative Names: TRPM8 control peptide, TRPM8 antibody Blocking Peptide, Anti-TRPM8 Blocking Peptide, Transient Receptor Potential Cation Channel Subfamily M Member 8 Blocking Peptide, LTRPC6 Blocking Peptide, MGC2849 Blocking Peptide, TRPP8 Blocking Peptide, TRPM8, TRPM-8, TRPM 8, TRPM-8 Blocking Peptide, TRPM 8 Blocking Peptide
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- 应用备注
- Optimal conditions should be determined by the investigator
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Add 100 µL of distilled water for a final peptide concentration is 1 mg/mL.
- 缓冲液
- PBS
- 注意事项
- Avoid repeated freeze/thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C long term.
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- 抗原
- TRPM8 (Transient Receptor Potential Cation Channel, Subfamily M, Member 8 (TRPM8))
- 别名
- TRPM8 Peptide, trpp8 Peptide, ltrpc6 Peptide, trpm8b Peptide, LTRPC6 Peptide, TRPP8 Peptide, CMR1 Peptide, LTrpC-6 Peptide, Trp-p8 Peptide, transient receptor potential cation channel subfamily M member 8 Peptide, transient receptor potential cation channel subfamily M member 8b L homeolog Peptide, transient receptor potential cation channel, subfamily M, member 8 Peptide, TRPM8 Peptide, trpm8b.L Peptide, Trpm8 Peptide
- 背景
- TRPM8 is the receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. TRPM8 is activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. TRPM8 is involved in menthol sensation. TRPM8 is permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. TRPM8 was activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonists menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing.
- 分子量
- 128 kDa
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