Signal-Regulatory Protein alpha (SIRPA) Peptide
SIRPA
适用: 人
宿主: 合成
BP, WB
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- 抗原 See all SIRPA products
- SIRPA (Signal-Regulatory Protein alpha (SIRPA))
- 宿主
- 人
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资源
- 合成
- 应用范围
- Blocking Peptide (BP), Western Blotting (WB)
- 产品特性
- This is a synthetic peptide designed for use in combination with anti-SIRPA antibody (Catalog #: AVARP00011_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- 纯化方法
- Purified
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- 应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- 浓度
- 1 mg/mL
- 缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- 抗原
- SIRPA (Signal-Regulatory Protein alpha (SIRPA))
- 别名
- BIT Peptide, CD172A Peptide, MFR Peptide, MYD-1 Peptide, P84 Peptide, PTPNS1 Peptide, SHPS1 Peptide, SIRP Peptide, SIRPA Peptide, SIRP-A1 Peptide, SIRP-B1 Peptide, AI835480 Peptide, Bit Peptide, CD172a Peptide, Ptpns1 Peptide, SHP-1 Peptide, SHPS-1 Peptide, swc3 Peptide, signal regulatory protein alpha Peptide, myeloperoxidase Peptide, signal-regulatory protein alpha Peptide, tyrosine-protein phosphatase non-receptor type substrate 1 Peptide, SIRPA Peptide, MPO Peptide, LOC458039 Peptide, LOC100400378 Peptide, LOC100590224 Peptide, Sirpa Peptide
- 背景
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SIRPA is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene.
Alias Symbols: BIT, CD172A, MFR, MYD-1, P84, PTPNS1, SHPS-1, SHPS1, SIRP, SIRP-ALPHA-1, SIRPalpha, SIRPalpha2
Protein Interaction Partner: CD47,IL1RAP,JAK2,NOL3,PTPN11,PTPN6,TRIM2,JAK2,NOL3,PTPN6,TRIM2
Protein Size: 504 - 分子量
- 52 kDa
- 基因ID
- 140885
- NCBI登录号
- NM_080792, NP_542970
- UniProt
- B2R6C3
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