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SIRPA 产品

(Signal-Regulatory Protein alpha (SIRPA))

Categories

Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of netrophils. [provided by RefSeq, Jul 2008].

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Featured SIRPA Categories

SIRPA 抗体

High quality antibodies with extensive validation data.

SIRPA ELISA试剂盒

Reliable ELISA kits for a wide range of species.

SIRPA 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended SIRPA 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, IF
Validations
  • (5)
Cat. No. ABIN530824
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, FACS, IHC, ELISA, ICC, Neut
Validations
  • (1)
  • (4)
Cat. No. ABIN5611267
Quantity 0.1 mg
Datasheet Datasheet
Reactivity Human
Application FACS, ELISA, IP, IF
Validations
  • (4)
Cat. No. ABIN6961045
Quantity 100 μg
Datasheet Datasheet

Recommended SIRPA ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6970225
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6962326
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6959481
Quantity 96 tests
Datasheet Datasheet

Recommended SIRPA 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (8)
Cat. No. ABIN7275652
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (4)
Cat. No. ABIN7275654
Quantity 100 μg
Datasheet Datasheet
Reactivity Cynomolgus
Source HEK-293 Cells
Validations
  • (4)
Cat. No. ABIN7275650
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our SIRPA Products

Andrejeva, Capoccia, Hiebsch, Donio, Darwech, Puro, Pereira: "Novel SIRPα Antibodies That Induce Single-Agent Phagocytosis of Tumor Cells while Preserving T Cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 206, Issue 4, pp. 712-721, (2021) (PubMed).

Li, Gu, Rao, Lu, Wen, Chen, Wang, Cui, Tang, Xu, Wang, Yu, Ge: "Luteolin promotes macrophage-mediated phagocytosis by inhibiting CD47 pyroglutamation." in: Translational oncology, Vol. 14, Issue 8, pp. 101129, (2021) (PubMed).

Deuse, Hu, Agbor-Enoh, Jang, Alawi, Saygi, Gravina, Tediashvili, Nguyen, Liu, Valantine, Lanier, Schrepfer: "The SIRPα-CD47 immune checkpoint in NK cells." in: The Journal of experimental medicine, Vol. 218, Issue 3, (2021) (PubMed).

Wang, Ni, Zhou, He, Gao, Wu, Wu, Wu, Qiu, Zhou, Chen, Pan, Huang, Li, Bian, Yang, Miao, Liu: "Tumor-selective blockade of CD47 signaling with a CD47/PD-L1 bispecific antibody for enhanced anti-tumor activity and limited toxicity." in: Cancer immunology, immunotherapy : CII, (2020) (PubMed).

Sarute, Ibrahim, Medegan Fagla, Lavanya, Cuevas, Stavrou, Otkiran-Clare, Tyynismaa, Henao-Mejia, Ross: "TRIM2, a novel member of the antiviral family, limits New World arenavirus entry." in: PLoS biology, Vol. 17, Issue 2, pp. e3000137, (2019) (PubMed).

Yu, Qiu, Long, Yang, Zhang, Xu, Chang, Du, Hou, Yu, Zeng, Wang, Sun: "A novel fully human anti-CD47 antibody as a potential therapy for human neoplasms with good safety." in: Biochimie, Vol. 151, pp. 54-66, (2018) (PubMed).

Londino, Gulick, Isenberg, Mallampalli: "Cleavage of Signal Regulatory Protein α (SIRPα) Enhances Inflammatory Signaling." in: The Journal of biological chemistry, Vol. 290, Issue 52, pp. 31113-25, (2015) (PubMed).

Jiang, Zhang, Gao, Zong, Zhou, Liu, Zhang, Bian, Zhu, Fan, Zhang, Li: "Signal regulatory protein-α protects against cardiac hypertrophy via the disruption of toll-like receptor 4 signaling." in: Hypertension (Dallas, Tex. : 1979), Vol. 63, Issue 1, pp. 96-104, (2013) (PubMed).

Price, Hope: "Enhanced secretion of interferon-gamma by bovine gammadelta T cells induced by coculture with Mycobacterium bovis-infected dendritic cells: evidence for reciprocal activating signals." in: Immunology, Vol. 126, Issue 2, pp. 201-8, (2009) (PubMed).

Waters, Palmer, Nonnecke, Thacker, Estes, Larsen, Jacobs, Andersen, McNair, Minion, Lyashchenko, Hewinson, Vordermeier, Sacco: "Signal regulatory protein alpha (SIRPalpha) cells in the adaptive response to ESAT-6/CFP-10 protein of tuberculous mycobacteria." in: PLoS ONE, Vol. 4, Issue 7, pp. e6414, (2009) (PubMed).

Synonyms and alternative names related to SIRPA

signal regulatory protein alpha (SIRPA), myeloperoxidase (MPO), signal-regulatory protein alpha (SIRPA), tyrosine-protein phosphatase non-receptor type substrate 1 (LOC458039), tyrosine-protein phosphatase non-receptor type substrate 1 (LOC100400378), tyrosine-protein phosphatase non-receptor type substrate 1 (LOC100590224), signal-regulatory protein alpha (Sirpa), AI835480, BIT, Bit, CD172A, CD172a, MFR, MYD-1, P84, PTPNS1, Ptpns1, SHP-1, SHPS-1, SHPS1, SIRP, SIRP-A1, SIRP-B1, SIRPA, swc3

Protein level used designations for SIRPA

  • CD172 antigen-like family member A
  • brain-immunoglobulin-like molecule with tyrosine-based activation motifs
  • inhibitory receptor SHPS-1
  • macrophage fusion receptor
  • myd-1 antigen
  • tyrosine phosphatase SHP substrate 1
  • tyrosine-protein phosphatase non-receptor type substrate 1
  • MyD-1 antigen
  • SHP substrate 1
  • SHPS-1
  • protein tyrosine phosphatase, non-receptor type substrate 1
  • signal-regulatory protein alpha-1
  • sirp-alpha-1
  • signal-regulatory protein alpha
  • signal regulatory protein alpha
  • tyrosine-protein phosphatase non-receptor type substrate 1-like
  • brain Ig-like molecule with tyrosine-based activation motifs
  • brain immunological-like with tyrosine-based motifs
  • mSIRP-alpha1
  • myD-1 antigen
  • Brain immunoglobulin like protein with tyrosine - based activation motifs
  • Protein tyrosine phosphatase non-receptor type substrate 1 (SHP substrate 1)
  • Protein tyrosine phosphatase, non-receptor type substrate 1 (SHP substrate 1)
  • macrophage membrane protein MFP150
  • swine workshop cluster 3 antigen
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