SIP1 产品
(Gem (Nuclear Organelle) Associated Protein 2 (GEMIN2))
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This gene encodes one of the proteins found in the SMN complex, which consists of several gemin proteins and the protein known as the survival of motor neuron protein. The SMN complex is localized to a subnuclear compartment called gems (gemini of coiled bodies) and is required for assembly of spliceosomal snRNPs and for pre-mRNA splicing. This protein interacts directly with the survival of motor neuron protein and it is required for formation of the SMN complex. A knockout mouse targeting the mouse homolog of this gene exhibited disrupted snRNP assembly and motor neuron degeneration. [provided by RefSeq, Aug 2011].
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Recommended SIP1 抗体
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Human, Mouse, Rat
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IHC, IF
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- (4)
Cat. No.
ABIN7010314
Quantity
60 μL
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Datasheet
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Human, Mouse, Rat
Application
WB, ELISA, IHC, ICC, IHC (p)
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- (4)
Cat. No.
ABIN625932
Quantity
0.05 mg
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Datasheet
Reactivity
Human
Application
WB, ELISA, IF, IP
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- (3)
Cat. No.
ABIN7153753
Quantity
100 μg
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Recommended SIP1 ELISA试剂盒
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Human
Analytical Method
Quantitative Sandwich ELISA
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Cat. No.
ABIN6231037
Quantity
96 tests
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Recommended SIP1 蛋白
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Source
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- (1)
Cat. No.
ABIN1320025
Quantity
10 μg
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Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
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- (1)
Cat. No.
ABIN3080724
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
Cat. No.
ABIN3128349
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our SIP1 Products
: "ZEB2 Represses the Epithelial Phenotype and Facilitates Metastasis in Ewing Sarcoma." in: Genes & cancer, Vol. 4, Issue 11-12, pp. 486-500, (2014) (PubMed).: "JARID2 is involved in transforming growth factor-beta-induced epithelial-mesenchymal transition of lung and colon cancer cell lines." in: PLoS ONE, Vol. 9, Issue 12, pp. e115684, (2014) (PubMed).
: "A novel function for the survival motoneuron protein as a translational regulator." in: Human molecular genetics, Vol. 22, Issue 4, pp. 668-84, (2013) (PubMed).
: "Proteomic assessment of a cell model of spinal muscular atrophy." in: BMC neuroscience, Vol. 12, pp. 25, (2011) (PubMed).
: "GEMIN2 promotes accumulation of RAD51 at double-strand breaks in homologous recombination." in: Nucleic acids research, Vol. 38, Issue 15, pp. 5059-74, (2010) (PubMed).
: "Novel monoclonal antibodies detect Smad-interacting protein 1 (SIP1) in the cytoplasm of human cells from multiple tumor tissue arrays." in: Experimental and molecular pathology, Vol. 89, Issue 2, pp. 182-9, (2010) (PubMed).
: "Regulation of SMN protein stability." in: Molecular and cellular biology, Vol. 29, Issue 5, pp. 1107-15, (2009) (PubMed).
: "SMN complex localizes to the sarcomeric Z-disc and is a proteolytic target of calpain." in: Human molecular genetics, Vol. 17, Issue 21, pp. 3399-410, (2008) (PubMed).
: "A novel cell response triggered by interphase centromere structural instability." in: The Journal of cell biology, Vol. 177, Issue 5, pp. 757-68, (2007) (PubMed).
: "Distinct domains of the spinal muscular atrophy protein SMN are required for targeting to Cajal bodies in mammalian cells." in: Journal of cell science, Vol. 119, Issue Pt 4, pp. 680-92, (2006) (PubMed).
Synonyms and alternative names related to SIP1
gem nuclear organelle associated protein 2 (GEMIN2), gem nuclear organelle associated protein 2 (Gemin2), gem (nuclear organelle) associated protein 2 (Gemin2), gem nuclear organelle associated protein 2 S homeolog (gemin2.S), gem (nuclear organelle) associated protein 2 (gemin2), 1700012N19Rik, SIP1, Sip1, sip1, SIP1-delta, sip1-delta, wu:fc52a05, zgc:110274Protein level used designations for SIP1
- SMN interacting protein 1-delta
- component of gems 2
- gem-associated protein 2
- gemin-2
- survival of motor neuron protein interacting protein 1
- SMN-interacting protein 1
- survival of motor neuron protein-interacting protein 1
- survivor of motor neuron protein interacting protein 1
- SMN interacting protein-1
- Survival of motor neuron protein-interacting protein 1
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