Major Histocompatibility Complex, Class II, DR beta 3 (HLA-DRB3) (C-Term) Peptide
HLA-DRB3
适用: 人
宿主: 合成
BP, WB
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- 抗原 See all HLA-DRB3 products
- HLA-DRB3 (Major Histocompatibility Complex, Class II, DR beta 3 (HLA-DRB3))
- 蛋白结构域
- C-Term
- 宿主
- 人
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资源
- 合成
- 应用范围
- Blocking Peptide (BP), Western Blotting (WB)
- 序列
- GFYPGSIEVR WFRNGQEEKA GVVSTGLIQN GDWTFQTLVM LETVPRSGEV
- 产品特性
- This is a synthetic peptide designed for use in combination with anti-HLA-DRB3 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- 纯化方法
- Purified
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- 应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- 浓度
- 1 mg/mL
- 缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- 抗原
- HLA-DRB3 (Major Histocompatibility Complex, Class II, DR beta 3 (HLA-DRB3))
- 别名
- HLA-DR3B Peptide, BLA-DRB3 Peptide, Bota-DRB01 Peptide, Bota-DRB02 Peptide, Bota-DRB04 Peptide, Bota-DRB07 Peptide, Bota-DRB21 Peptide, Bota-DRB22 Peptide, LA-DRB Peptide, major histocompatibility complex, class II, DR beta 3 Peptide, major histocompatibility complex, class II, DRB3 Peptide, HLA-DRB3 Peptide, BOLA-DRB3 Peptide
- 背景
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HLA-DRB3 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB3 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.
Alias Symbols: HLA-DR3B, HLA-DR52, HLA-DRB1, MGC117330
Protein Interaction Partner: CTAG1B,POMC,POMC
Protein Size: 266 - 分子量
- 27 kDa
- 基因ID
- 3125
- NCBI登录号
- NM_022555, NP_072049
- UniProt
- P13762
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