Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
产品特性
This is a synthetic peptide designed for use in combination with anti-HIF1A antibody (Catalog #: AVARP20009_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
Hypoxia-inducible factor-1 (HIF1) is a transcription factor found in mammalian cells cultured under reduced oxygen tension that plays an essential role in cellular and systemic homeostatic responses to hypoxia. HIF1 is a heterodimer composed of an alpha subunit and a beta subunit. The beta subunit has been identified as the aryl hydrocarbon receptor nuclear translocator (ARNT). HIF1A is the alpha subunit of HIF-1. Overexpression of a natural antisense transcript (aHIF) of this gene has been shown to be associated with nonpapillary renal carcinomas. Two alternative transcripts encoding different isoforms have been identified.
Alias Symbols: HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78
Protein Interaction Partner: ARNT,ARNT,CDKN2A,COPS5,EGLN1,EGLN3,EPO,OS9,RB1,TP53,TP53,VEGFA,VHL,VHL,VHL,ARNT,ARNT,TP53,APEX1,AR,ARNT,ARNT2,ARNTL,CDKN2A,CITED2,COPS5,CREBBP,CSNK2A1,CTNNB1,DAP3,EGLN1,EGLN2,EGLN3,EP300,HDAC1,HIF1AN,HIF3A,HSP90AA1,JUN,MAPK3,MAX,MDM2,MTA1,NAA10,NAA11,NCOA1,NCOA2,NDN,OS9,PER1,PGK1,PSMA7,SEPT9,SP1,SSX4B,STAT3,TP53,TSGA10,VHL,VHLL,APEX1,ARNT,ARNT,ARNTL,CDKN1A,CREBBP,CUL2,DAP3,EP300,GNB2L1,HDAC1,HDAC2,HDAC3,HIF1AN,HSP90AA1,JUN,MDM2,MTA1,Mapk1,NAA10,NCOA1,NR4A1,PSMA7,PSMC3,Per1,SAT1,SAT2,SP1,SSX4,STAT3,TCEB1,TP53,UBC,VHL,Vhl,ZNF197