Protein Kinase A, alpha (PRKACA) (N-Term) Peptide
PRKACA
适用: 人
宿主: 合成
BP, WB
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- 抗原 See all PRKACA products
- PRKACA (Protein Kinase A, alpha (PRKACA))
- 蛋白结构域
- N-Term
- 宿主
- 人
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资源
- 合成
- 应用范围
- Blocking Peptide (BP), Western Blotting (WB)
- 序列
- FLKKWESPAQ NTAHLDQFER IKTLGTGSFG RVMLVKHKET GNHYAMKILD
- 产品特性
- This is a synthetic peptide designed for use in combination with anti- PRKACA Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- 储存条件
- -20 °C
- 储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- 抗原
- PRKACA (Protein Kinase A, alpha (PRKACA))
- 别名
- PKACA Peptide, Calpha Peptide, Cs-PKA Peptide, PKCA1 Peptide, PKA Peptide, PKCD Peptide, Pkaca Peptide, zgc:158799 Peptide, protein kinase cAMP-activated catalytic subunit alpha Peptide, protein kinase, cAMP dependent, catalytic, alpha Peptide, cAMP-dependent protein kinase catalytic subunit Peptide, protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a Peptide, PRKACA Peptide, Prkaca Peptide, kin-1 Peptide, prkacaa Peptide
- 背景
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This gene encodes one of the catalytic subunits of protein kinase A, which exists as a tetrameric holoenzyme with two regulatory subunits and two catalytic subunits, in its inactive form. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. cAMP-dependent phosphorylation of proteins by protein kinase A is important to many cellular processes, including differentiation, proliferation, and apoptosis. Constitutive activation of this gene caused either by somatic mutations, or genomic duplications of regions that include this gene, have been associated with hyperplasias and adenomas of the adrenal cortex and are linked to corticotropin-independent Cushing's syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. Tissue-specific isoforms that differ at the N-terminus have been described, and these isoforms may differ in the post-translational modifications that occur at the N-terminus of some isoforms.
Alias Symbols: PKACA, PPNAD4
Protein Size: 351 - 基因ID
- 5566
- NCBI登录号
- NM_001304349, NP_001291278
- UniProt
- P17612
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