WW Domain Containing Transcription Regulator 1 (WWTR1) (C-Term) Peptide
WWTR1
适用: 人
宿主: 合成
BP, WB
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- 抗原 See all WWTR1 products
- WWTR1 (WW Domain Containing Transcription Regulator 1 (WWTR1))
- 蛋白结构域
- C-Term
- 宿主
- 人
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资源
- 合成
- 应用范围
- Blocking Peptide (BP), Western Blotting (WB)
- 序列
- PPTMTPDMRS ITNNSSDPFL NGGPYHSREQ STDSGLGLGC YSVPTTPEDF
- 产品特性
- This is a synthetic peptide designed for use in combination with anti-WWTR1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- 储存条件
- -20 °C
- 储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- 抗原
- WWTR1 (WW Domain Containing Transcription Regulator 1 (WWTR1))
- 别名
- WWTR1 Peptide, TAZ Peptide, 2310058J06Rik Peptide, 2610021I22Rik Peptide, C78399 Peptide, Taz Peptide, WW domain containing transcription regulator 1 L homeolog Peptide, WW domain containing transcription regulator 1 Peptide, wwtr1.L Peptide, wwtr1 Peptide, WWTR1 Peptide, Wwtr1 Peptide
- 背景
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WWTR1 is a transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. It regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. And it regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition.
Alias Symbols: WWTR1,TAZ,
Protein Size: 400 - 基因ID
- 25937
- NCBI登录号
- NP_056287
- UniProt
- Q9GZV5
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