DNA Repair Protein Complementing XP-G Cells (ERCC5) (N-Term) Peptide
ERCC5
适用: 人
宿主: 合成
BP, WB
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- 抗原 See all ERCC5 products
- ERCC5 (DNA Repair Protein Complementing XP-G Cells (ERCC5))
- 蛋白结构域
- N-Term
- 宿主
- 人
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资源
- 合成
- 应用范围
- Blocking Peptide (BP), Western Blotting (WB)
- 序列
- HSGHIRRQYE DEGGFLKEVE SRRVVSEDTS HYILIKGIQA KTVAEVDSES
- 产品特性
- This is a synthetic peptide designed for use in combination with anti-ERCC5 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- 纯化方法
- Purified
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- 浓度
- 1 mg/mL
- 缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
- 注意事项
- Avoid repeat freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- 抗原
- ERCC5 (DNA Repair Protein Complementing XP-G Cells (ERCC5))
- 别名
- COFS3 Peptide, ERCM2 Peptide, UVDR Peptide, XPG Peptide, XPGC Peptide, cofs3 Peptide, ercm2 Peptide, uvdr Peptide, xpg Peptide, xpgc Peptide, Xpg Peptide, ERCC excision repair 5, endonuclease Peptide, excision repair cross-complementation group 5 L homeolog Peptide, excision repair cross-complementing rodent repair deficiency, complementation group 5 Peptide, ERCC5 Peptide, ercc5.L Peptide, Ercc5 Peptide
- 背景
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This gene encodes a single-strand specific DNA endonuclease that makes the 3' incision in DNA excision repair following UV-induced damage. The protein may also function in other cellular processes, including RNA polymerase II transcription, and transcription-coupled DNA repair. Mutations in this gene cause xeroderma pigmentosum complementation group G (XP-G), which is also referred to as xeroderma pigmentosum VII (XP7), a skin disorder characterized by hypersensitivity to UV light and increased susceptibility for skin cancer development following UV exposure. Some patients also develop Cockayne syndrome, which is characterized by severe growth defects, mental retardation, and cachexia. Read-through transcription exists between this gene and the neighboring upstream BIVM (basic, immunoglobulin-like variable motif containing) gene.
Protein Size: 1180 - 分子量
- 130 kDa
- 基因ID
- 2073
- UniProt
- P28715
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