Chromosome 1 Open Reading Frame 124 (C1orf124) (Middle Region) Peptide
C1orf124
适用: 人
宿主: 合成
BP, WB
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- 抗原 See all Spartan (C1orf124) products
- Spartan (C1orf124) (Chromosome 1 Open Reading Frame 124 (C1orf124))
- 蛋白结构域
- Middle Region
- 宿主
- 人
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资源
- 合成
- 应用范围
- Blocking Peptide (BP), Western Blotting (WB)
- 序列
- ATNREPSAHD YWWAEHQKTC GGTYIKIKEP ENYSKKGKGK AKLGKEPVLA
- 产品特性
- This is a synthetic peptide designed for use in combination with anti-SPRTN Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- 纯化方法
- Purified
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- 应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- 浓度
- 1 mg/mL
- 缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- 抗原
- Spartan (C1orf124) (Chromosome 1 Open Reading Frame 124 (C1orf124))
- 别名
- Spartan Peptide, c1orf124 Peptide, C1orf124 Peptide, DDDL1880 Peptide, DVC1 Peptide, PRO4323 Peptide, dJ876B10.3 Peptide, C28H1orf124 Peptide, SprT-like N-terminal domain Peptide, sprtn Peptide, SPRTN Peptide
- 背景
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SPRTN is a regulator of UV-induced DNA damage response: acts as a 'reader' of ubiquitinated PCNA that enhances RAD18-mediated PCNA ubiquitination and translesion DNA synthesis. SPRTN is recruited to sites of UV damage and interacts with ubiquitinated PCNA and RAD18, the E3 ubiquitin ligase that monoubiquitinates PCNA. It facilitates chromatin association of RAD18 and is required for efficient PCNA monoubiquitination, promoting a feed-forward loop to enhance PCNA ubiquitination and translesion DNA synthesis. It is also required for localization of DNA polymerase eta (POLH) to sites of UV damage.
Alias Symbols: C1orf124, DDDL1880, PRO4323, Spartan, dJ876B10.3
Protein Size: 489 - 分子量
- 55 kDa
- 基因ID
- 83932
- NCBI登录号
- NM_032018, NP_114407
- UniProt
- Q9H040
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