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Spartan 产品

(Chromosome 1 Open Reading Frame 124 (C1orf124))

Categories

Regulator of UV-induced DNA damage response: acts as a 'reader' of ubiquitinated PCNA that enhances RAD18-mediated PCNA ubiquitination and translesion DNA synthesis (TLS). Recruited to sites of UV damage and interacts with ubiquitinated PCNA and RAD18, the E3 ubiquitin ligase that monoubiquitinates PCNA. Facilitates chromatin association of RAD18 and is required for efficient PCNA monoubiquitination, promoting a feed-forward loop to enhance PCNA ubiquitination and translesion DNA synthesis. Acts as a regulator of TLS by recruiting VCP/p97 to sites of DNA damage, possibly leading to extraction of DNA polymerase eta (POLH) by VCP/p97 to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage (By similarity). {ECO:0000250}.

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Recommended Spartan 抗体

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Datasheet
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Recommended Spartan 蛋白

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Cat. No. ABIN3095643
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Latest Publications for our Spartan Products

Stadler, Rexhepaj, Singan, Murphy, Pepperkok, Uhlén, Simpson, Lundberg: "Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells." in: Nature methods, Vol. 10, Issue 4, pp. 315-23, (2013) (PubMed).

Mosbech, Gibbs-Seymour, Kagias, Thorslund, Beli, Povlsen, Nielsen, Smedegaard, Sedgwick, Lukas, Hartmann-Petersen, Lukas, Choudhary, Pocock, Bekker-Jensen, Mailand: "DVC1 (C1orf124) is a DNA damage-targeting p97 adaptor that promotes ubiquitin-dependent responses to replication blocks." in: Nature structural & molecular biology, Vol. 19, Issue 11, pp. 1084-92, (2012) (PubMed).

Synonyms and alternative names related to Spartan

SprT-like N-terminal domain (sprtn), SprT-like N-terminal domain (SPRTN), c1orf124, C1orf124, C28H1orf124, DDDL1880, dJ876B10.3, DVC1, PRO4323, Spartan

Protein level used designations for Spartan

  • Protein with SprT-like domain at the N terminus
  • sprT-like domain-containing protein Spartan
  • DNA damage protein targeting VCP
  • DNA damage-targeting VCP (p97) adaptor
  • SprT-like domain at the N terminus
  • protein with SprT-like domain at the N terminus
  • zinc finger RAD18 domain-containing protein C1orf124
  • spartan
  • zinc finger RAD18 domain-containing protein C1orf124 homolog
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