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Plasma membrane polyphosphoinositides depletion caused rapid translocation of K-Ras4B but not H-Ras from the plasma membrane to the Golgi.
Data show that an indispensable beta-subunit (显示 POLG 蛋白) of the voltage-gated Ca(2 (显示 CA2 蛋白)+) channel Cav1.2 (显示 CACNA1C 蛋白) interaction with H-Ras is independently of Ca(2 (显示 CA2 蛋白)+) flux, suggesting the regulatory role of beta2 in transcriptional activation via the ERK (显示 EPHB2 蛋白)/CREB (显示 CREB1 蛋白) pathway.
This study demonstrated that Oligodendrocyte RasG12V expressed in its endogenous locus disrupts myelin structure through increased MAPK (显示 MAPK1 蛋白), nitric oxide, and notch (显示 NOTCH1 蛋白) signaling.
Data indicate dynamic of H-Ras functional cycle as controlled by son of sevenless homolog 1 (显示 SOS1 蛋白) (Sos).
Our data support the idea that a variable range of dysregulated HRAS-dependent signalling dynamics, rather than static activation of HRAS-dependent signal flow, may underlie the phenotypic variability in CS.
AF6 employs a non-canonical, evolutionarily conserved alpha-helix to bind RAS, unique to AF6 and the classical RASSF effectors.
Case Report: somatic HRAS mutation in pigmented trichoblastoma developed in a sebaceous nevus.
our identification of the novel interaction between Aurora A (显示 AURKA 蛋白) and H-Ras as a mechanism by which Aurora A (显示 AURKA 蛋白) can activate Ras-MAPK (显示 MAPK1 蛋白) signaling opens the way for studies into perturbation of the Aurora A (显示 AURKA 蛋白)/H-Ras interaction and the effect on Ras-MAPK (显示 MAPK1 蛋白) signaling.
Peroxiredoxin I (Prx (显示 PRDX6 蛋白) I) increased in tumors of hepatocellular carcinoma (HCC (显示 FAM126A 蛋白)) patients that aligned with overexpression of oncogenic H-ras.
Familial alcohol dependence was associated with hypomethylation of CpG sites in the HRAS promoter region.
Kita driven expression of oncogenic HRAS leads to early onset and highly penetrant melanoma in zebrafish
Data demonstrate that H-Ras activation is important in the activation of the specific signaling events leading to the accelerated retinal capillary cell apoptosis in hyperglycemic conditions.
Activation of H-Ras and its downstream signaling pathway in the retina and its vasculature could be under the control of superoxide, and H-Ras activation in diabetes can be prevented by inhibiting superoxide accumulation.
Thrombospondin 1 (显示 THBS1 蛋白), fibronectin (显示 FN1 蛋白), and vitronectin (显示 VTN 蛋白) are differentially dependent upon RAS, ERK1/2, and p38 (显示 MAPK14 蛋白) for induction of vascular smooth muscle cell chemotaxis.
gene expression profiles of each of the Ras isoforms in a panel of mouse tissues derived from a full developmental time course, are reported.
This study demonstrates that H- ras deletion protects against AngII-induced cardiac remodeling, possibly via a mechanism in which PKG (显示 PRKG1 蛋白)-Ibeta overexpression could play a partial role, and points to H-Ras and/or downstream proteins as potential therapeutic targets in cardiovascular disease.
HRas (G12V/G12V) mice showed robust upregulation of ERK (显示 EPHB2 蛋白) signaling, neuronal hypertrophy, increased brain volume, spatial learning deficits, and impaired mGluR (显示 GRM8 蛋白)-dependent long-term depression (LTD).
the oncogenic Hras mutation modulates energy homeostasis in vivo.
Loss of wild-type Hras promotes the earliest stages of pancreatic tumorigenesis, and moreover results in more rapid progression of the disease. As such, mechanisms leading to activation of wild-type Ras proteins, including but not limited to redox-dependent reactions, may influence the development of pancreatic cancer.
High HRAS expression is associated with hepatocarcinogenesis.
p21-associated inhibition of early-stage malignant progression and the intense expression in papilloma outgrowths, identifies a novel, significant antagonism between p21 and ras(Ha)/ROCK2 (显示 ROCK2 蛋白)/NF-kappaB (显示 NFKB1 蛋白) signalling in skin carcinogenesis.these data show that ROCK2 (显示 ROCK2 蛋白) activation induces malignancy in ras(Ha)-initiated/promoted papillomas in the context of p53 (显示 TP53 蛋白) loss and novel NF-kappaB (显示 NFKB1 蛋白) expression
this study shows that retinoic acid stabilizes HRas protein during neurogenesis.
we provide genetic evidence that the wild-type H-Ras and K-Ras proteins are bioequivalent in spite of their different structural and biological properties
loss of one allele of Hras increased the sensitivity of mice to this carcinogen, and this effect was further exacerbated by the loss of the second Hras allele. However, loss of one or both alleles of Nras (显示 NRAS 蛋白) failed to alter tumor burden, either in the absence or presence of Hras, after exposure to urethane.
This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene.
GTP- and GDP-binding peptide B
, GTPase HRas
, Ha-Ras1 proto-oncoprotein
, Ras family small GTP binding protein H-Ras
, c-has/bas p21 protein
, c-ras-Ki-2 activated oncogene
, p19 H-RasIDX protein
, transformation gene: oncogene HAMSV
, transforming protein p21
, v-Ha-ras Harvey rat sarcoma viral oncogene homolog
, Transforming protein p21
, neuroblastoma ras oncogene
, v-Ha-ras Harvey rat sarcoma viral oncogene-like protein
, Harvey ras1 protein
, Harvey rat sarcoma viral (v-Ha-ras) oncogene homolog
, ras p21
, small G-protein H-Ras
, GTPase HRas (Transforming protein p21) (H-Ras-1) (c-H-ras)
, Harvey ras 1
, H-ras 1 protein
, c-Ha-ras p21 protein
, c-Ha-ras transgene
, transforming protein P21