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Human E2F1 Protein expressed in HEK-293 Cells - ABIN2719894
Tarangelo, Lo, Teng, Kim, Le, Watson, Furth, Raman, Ehmer, Viatour: Recruitment of Pontin/Reptin by E2f1 amplifies E2f transcriptional response during cancer progression. in Nature communications 2015
dE2F1b is a novel member of the E2F (显示 E2F2 蛋白) family, revealing a previously unappreciated complexity in the Drosophila RB/E2F (显示 E2F2 蛋白) network.
specific alternate transcripts of activator E2F (显示 E2F2 蛋白), dE2F1, may have a dual function on cell cycle progression and cannot simply be viewed as a pro-proliferative transcription factor
These findings identify a key function of E2F in skeletal muscle required for animal viability, and illustrate how the cell cycle regulator is repurposed in post-mitotic cells.
Mechanistically, miR (显示 MYLIP 蛋白)-998 operates by repressing dCbl, a negative regulator of EGFR (显示 EGFR 蛋白) signaling. Significantly, dCbl is a critical target of miR (显示 MYLIP 蛋白)-998 since dCbl phenocopies the effects of miR (显示 MYLIP 蛋白)-998 on dE2f1-dependent apoptosis in rbf (显示 ATP5I 蛋白) mutants
also demonstrated that an optimum level of dLin52 is needed for dE2F1/2 activity on the hid promoter
Results show that regulation of e2f1 and PCNA (显示 PCNA 蛋白) by DREF (显示 ZBED1 蛋白) in vivo is complex and the regulation mechanism may differ with the tissue and/or positions in the tissue.
Loss of dE2F compromises mitochondrial function.
Data propose that the interaction between ORC5 (显示 ORC5 蛋白) and dE2F1 may reflect a feedback mechanism between replication initiation proteins and dE2F1 that ensures that proliferating cells maintain a robust level of replication proteins for the next cell cycle.
results suggest that E2F/DP complexes are essential for all genomic targeting of RBF1
Inappropriate accumulation of E2f1 protein during S phase triggers the elimination of potentially hyperplastic cells via apoptosis in order to ensure normal development of rapidly proliferating tissues.
PPM1B (显示 PPM1B 蛋白) plays a negative role in the activation of the p38 (显示 CRK 蛋白)-RB1 (显示 RB1 蛋白)-E2F1 pathway and that targeting PPM1B (显示 PPM1B 蛋白) could be useful in certain types of cancer by stimulating chemotherapy-induced cell death.
Studied impact of BET proteins and E2F transcription factor 1 (E2F1) in neoplastic genetic transcription in glioblastoma.
E2F1 knockdown decreased the expression of discoidin domain receptor (显示 DDR1 蛋白) 1 (DDR1 (显示 DDR1 蛋白)) which plays a crucial role in many fundamental processes such as cell differentiation, adhesion, migration and invasion.
Our data imply that downregulation of E2F1 may be a key factor in the celastrol-mediated inhibitory effects in HepG2 cells, and celastrol can serve as a leading compound for the development of compounds designed to inactivate E2F1 for hepatocellular carcinoma therapy
SNHG16 promotes glioma tumorigenesis by sponging miR (显示 MLXIP 蛋白)-20a-5p, leading to the enhancement of its endogenous targets E2F1
These results demonstrate that gambogic acid sensitizes pancreatic cancer cells to gemcitabine in vitro and in vivo by inhibiting the activation of the ERK (显示 EPHB2 蛋白)/E2F1/RRM2 (显示 RRM2 蛋白) signaling pathway.
Reports showed that high expression of the transcription factor E2F1 was involved in the invasion and metastasis of small cell lung cancer (SCLC). Further results provided evidence that E2F1 promoted EMT (显示 ITK 蛋白) by regulating ZEB2 (显示 ZEB2 蛋白) gene expression in SCLC.
By comparison in HeLa, Dox induced apoptosis through upregulation of endogenous E2F1 involving post-transcriptional mechanisms, while E2F6 (显示 E2F6 蛋白) was down regulated with induction of the Checkpoint kinase-1 (显示 CHEK1 蛋白) and proteasome degradation. These data imply that E2F6 (显示 E2F6 蛋白) serves to modulate E2F activity and protect cells including cardiomyocytes from apoptosis and improve survival.
This study reveals a molecular pathway involving lncRNA GAS5/E2F1/P27(Kip1 (显示 CDKN1B 蛋白)) which regulates cell proliferation and could be a potential therapeutic target in prostate cancer.
E2F1 induces TINCR transcriptional activity and accelerates gastric cancer progression via activation of TINCR/STAU1 (显示 STAU1 蛋白)/CDKN2B (显示 CDKN2B 蛋白) signaling axis.
E2f1 mediates high glucose-induced neuronal death in cultured mouse retinal explants.
p63alpha protein up-regulates heat shock protein 70 (显示 HSP70 蛋白) expression via E2F1 transcription factor 1 (显示 HNF1A 蛋白), promoting Wasf3/Wave3 (显示 WASF3 蛋白)/MMP9 (显示 MMP9 蛋白) signaling and bladder cancer invasion
The evidence has been presented that the retinoblastoma protein utilizes a cell-cycle-independent interaction with E2F1 to recruit EZH2 (显示 EZH2 蛋白) to diverse repeat sequences.
germ-line loss of E2f1 or E2f3b, but not E2f3a, protected mice against hepatocellular carcinoma
E2F1 hinders skin wound healing by suppressing VEGF (显示 VEGFA 蛋白) expression, neovascularization, and macrophage recruitment. Strategies that target E2F1 may enhance wound healing.
systems-level control of cell cycle arrest by pRB (显示 PGR 蛋白)-E2F and p27 (显示 CDKN1B 蛋白)-CDK (显示 CDK4 蛋白) regulation, is reported.
TERT (显示 TERT 蛋白) has a role in neointima formation through epigenetic regulation of proliferative E2F1 target gene expression in smooth muscle cells.
inhibition of PDK4 (显示 PDK4 蛋白) activity in Hepatocellular carcinoma cells increased cyclin E1 (显示 CCNE1 蛋白), cyclin A2 (显示 CCNA2 蛋白), and E2F1 proteins.
Data indicate that adenosine and CGS21680 upregulate CD39 (显示 ENTPD1 蛋白) and CD73 via E2F-1 and CREB (显示 CREB1 蛋白).
Expression of Kv10.1 (显示 KCNG3 蛋白) driven by phosphorylated Rb/E2F1 contributes to G2/M progression of cancer and non-transformed cells.
Xphb1 represses E2F1 activity.
SIM (显示 SIM2 蛋白) and SMR1 are involved in hyperphosphorylation of the cell-cycle regulator RBR1 and overexpression of E2F target genes.
S6K1 interacts with retinoblastoma protein RBR via its N-terminal RBR binding motif, promotes its nuclear localization and consequent RBR-dependent repression of cell cycle genes through transcription factor E2FB.
The Arabidopsis (Arabidopsis thaliana) DEL1 gene was identified as a transcriptional target of the classical E2Fb and E2Fc transcription factors.
The authors found that S6K1 associates with the Retinoblastoma-related 1 (RBR1)-E2FB complex and this is partly mediated by its N-terminal LVxCxE motif.
Results suggest that E2FB is one of the key targets for auxin to determine whether cells proliferate or whether they exit the cell cycle, enlarge, and endoreduplicate their DNA.
AtE2Fa and AtE2Fb have specific expression patterns and may play similar but distinct roles during cell cycle progression.
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis.
, E2-promoter binding factor
, PRB-binding protein E2F-1
, retinoblastoma-associated protein 1
, retinoblastoma-binding protein 3
, transcription factor E2F1
, E2F-1 transcription factor