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E2F1 Protein (Myc-DYKDDDDK Tag)

E2F1 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
产品编号 ABIN2719894
发货至: 中国
  • 抗原 See all E2F1 蛋白
    E2F1 (E2F Transcription Factor 1 (E2F1))
    蛋白类型
    Recombinant
    宿主
    • 4
    • 2
    • 1
    • 1
    • 1
    资源
    • 2
    • 2
    • 2
    • 1
    HEK-293 Cells
    标记
    This E2F1 protein is labelled with Myc-DYKDDDDK Tag.
    应用范围
    Antibody Production (AbP), Standard (STD)
    产品特性
    • Recombinant human E2F1 protein expressed in HEK293 cells.
    • Produced with end-sequenced ORF clone
    纯度
    > 80 % as determined by SDS-PAGE and Coomassie blue staining
    Top Product
    Discover our top product E2F1 蛋白
  • 应用备注
    Recombinant human proteins can be used for:
    Native antigens for optimized antibody production
    Positive controls in ELISA and other antibody assays
    说明

    The tag is located at the C-terminal.

    限制
    仅限研究用
  • 浓度
    50 μg/mL
    缓冲液
    25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
    储存条件
    -80 °C
    储存方法
    Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
  • Tarangelo, Lo, Teng, Kim, Le, Watson, Furth, Raman, Ehmer, Viatour: "Recruitment of Pontin/Reptin by E2f1 amplifies E2f transcriptional response during cancer progression." in: Nature communications, Vol. 6, pp. 10028, (2015) (PubMed).

  • 抗原
    E2F1 (E2F Transcription Factor 1 (E2F1))
    别名
    e2f1 (E2F1 产品)
    别名
    CG6376 Protein, DRTF1/E2F Protein, DmE2F-1 Protein, Dmel\\CG6376 Protein, Dp Protein, E(Sev-CycE)3A Protein, E(var)3-93E Protein, E(var)3-95E Protein, E(var)93E Protein, E2F Protein, E2F-1 Protein, E2F1 Protein, E2f1 Protein, Evar(3)164 Protein, dE2F Protein, dE2F1 Protein, dE2f Protein, dE2f1 Protein, de2f1 Protein, def21 Protein, drosE2F1 Protein, e2f Protein, e2f1 Protein, l(3)07172 Protein, l(3)j3B1 Protein, l(3)j3C2 Protein, l(3)rM729 Protein, RBAP1 Protein, RBBP3 Protein, RBP3 Protein, mKIAA4009 Protein, xE2F Protein, ATE2FB Protein, E2F TRANSCRIPTION FACTOR-1 E2F1 Protein, E2F transcription factor 1 Protein, E2FB Protein, E2FB TRANSCRIPTION FACTOR Protein, E2F transcription factor 1 Protein, E2F transcription factor 1 L homeolog Protein, E2f1 Protein, E2F1 Protein, e2f1.L Protein
    背景
    The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis.
    分子量
    46.7 kDa
    NCBI登录号
    NP_005216
    途径
    p53 Pathway, Cell Division Cycle, Mitotic G1-G1/S Phases, DNA Replication, M Phase, Autophagy
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