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抗Human Integrin beta 2 抗体:
抗Mouse (Murine) Integrin beta 2 抗体:
抗Rat (Rattus) Integrin beta 2 抗体:
Mouse (Murine) Monoclonal Integrin beta 2 Primary Antibody for FACS, Func - ABIN457404
Abraham, Miller: Molecular mechanisms of IL-2 gene regulation following costimulation through LFA-1. in Journal of immunology (Baltimore, Md. : 1950) 2001
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Mouse (Murine) Monoclonal Integrin beta 2 Primary Antibody for FACS, Func - ABIN457348
Avni, Pur, Yefenof, Baniyash: Complement receptor 3 of macrophages is associated with galectin-1-like protein. in Journal of immunology (Baltimore, Md. : 1950) 1998
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Mouse (Murine) Monoclonal Integrin beta 2 Primary Antibody for FACS, Func - ABIN457430
Sakurai, Taguchi, Anand, Ambati, Gragoudas, Miller, Adamis, Ambati: Targeted disruption of the CD18 or ICAM-1 gene inhibits choroidal neovascularization. in Investigative ophthalmology & visual science 2003
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Mouse (Murine) Monoclonal Integrin beta 2 Primary Antibody for BR, IHC (f) - ABIN2689033
Driessens, van Hulten, Zuurbier, La Rivière, Roos: Inhibition and stimulation of LFA-1 and Mac-1 functions by antibodies against murine CD18. Evidence that the LFA-1 binding sites for ICAM-1, -2, and -3 are distinct. in Journal of leukocyte biology 1997
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Mouse (Murine) Monoclonal Integrin beta 2 Primary Antibody for BR, Func - ABIN1176975
Isobe, Yagita, Okumura, Ihara: Specific acceptance of cardiac allograft after treatment with antibodies to ICAM-1 and LFA-1. in Science (New York, N.Y.) 1992
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Human Monoclonal Integrin beta 2 Primary Antibody for Func, IHC (f) - ABIN2749019
Dassanayake, Maheswaran, Srikumaran: Monomeric expression of bovine beta2-integrin subunits reveals their role in Mannheimia haemolytica leukotoxin-induced biological effects. in Infection and immunity 2007
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Human Monoclonal Integrin beta 2 Primary Antibody for FACS, Func - ABIN192094
Cera, Fabbri, Molendini, Corada, Orsenigo, Rehberg, Reichel, Krombach, Pardi, Dejana: JAM-A promotes neutrophil chemotaxis by controlling integrin internalization and recycling. in Journal of cell science 2009
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Human Monoclonal Integrin beta 2 Primary Antibody for FACS, Func - ABIN94008
Nakayama, Yoshizaki, Prinetti, Sonnino, Mauri, Takamori, Ogawa, Iwabuchi: Lyn-coupled LacCer-enriched lipid rafts are required for CD11b/CD18-mediated neutrophil phagocytosis of nonopsonized microorganisms. in Journal of leukocyte biology 2008
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Human Monoclonal Integrin beta 2 Primary Antibody for FACS, Func - ABIN94007
Sewald, Gebert-Vogl, Prassl, Barwig, Weiss, Fabbri, Osicka, Schiemann, Busch, Semmrich, Holzmann, Sebo, Haas: Integrin subunit CD18 Is the T-lymphocyte receptor for the Helicobacter pylori vacuolating cytotoxin. in Cell host & microbe 2008
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Human Monoclonal Integrin beta 2 Primary Antibody for FACS, Func - ABIN94005
Morova, Osicka, Masin, Sebo: RTX cytotoxins recognize beta2 integrin receptors through N-linked oligosaccharides. in Proceedings of the National Academy of Sciences of the United States of America 2008
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Overexpression of ITGB2 was not correlated with ITGB2 promoter hypomethylation in systemic sclerosis.
actin engagement produces tension within the beta2 subunit to induce and stabilize an active integrin conformational state and that this requires intact talin and kindlin motifs.
on tumour-infiltrating T-lymphocytes, galectin prevents the formation of a functional secretory synapse by preventing optimal LFA-1 (显示 ITGAL 抗体) triggering
exploration of the underlying mechanism demonstrated that ICAM3 (显示 ICAM3 抗体) not only binds to LFA-1 (显示 ITGAL 抗体) with its extracellular domain and structure protein ERM (显示 ETV5 抗体) but also to lamellipodia with its intracellular domain which causes a tension that pulls cells apart (metastasis).
vesicle-associated RhoB is a regulator of the Rab11 (显示 RAB11A 抗体)-mediated recycling of LFA-1 (显示 ITGAL 抗体) to the cell surface, an event that is necessary for T lymphocyte motility.
The ITGB2 variant rs2230531 was examined in an independent cohort of Tasmanian patients with hematologic malignancies (HM) to see if its presence correlated with chronic lymphocytic leukemia. The variant was found in several lymphoid and myeloid HMs (显示 CTSC 抗体), so if contributes to the risk of HM, it does so broadly across HM subtypes in this population.
Data suggest that the residue volume at phenylalanine (Phe) in alpha1-helix is critical for alpha(L)/beta(2) integrin (CD49a (显示 ITGA1 抗体)/CD18) activation and binding with soluble/immobilized ICAM1 (显示 ICAM1 抗体) (intercellular cell adhesion molecule 1 (显示 CADM1 抗体)).
an integrated strategy of whole genome and transcriptome analysis enabled identification of LB-ITGB2-1 as HLA-B*15:01-restricted MiHAs encoded by an alternative transcript. The alternative ITGB2 transcript was shown to be expressed in leukemic cells of different origins.
Neutrophil rolling over E-selectin (显示 SELE 抗体) at precise shear stress transmits tension and catch-bond formation with L-selectin (显示 SELL 抗体) via sLe(x), resulting in focal clusters that deliver a distinct signal to upshift beta2-integrins to a high-affinity state. Rivipansel effectively blocked formation of selectin catch-bonds, revealing a novel mechanotransduction circuit
CD177 (显示 CD177 抗体) signals in a beta2 integrin-dependent manner to orchestrate a set of activation-mediated mechanisms that impair human neutrophil migration.
A modulatory role for the tumor beta2 subunit of the LFA-1 (显示 ITGAL 抗体) integrin in the metastatic progression of colorectal cancer to the liver by impaired activation of liver endothelium.
Data show CD18 is selectively required for T helper 2, but not T helper 1, homing and has a minimal influence on T-effector development.
Adhesive properties of the leukocyte integrin Mac-1 (显示 ITGAM 抗体) are not required for macrophage accumulation in adipose tissue. Instead, Mac-1 (显示 ITGAM 抗体) modulates inflammatory gene expression in macrophages.
in T cells, PI3Kdelta attenuates the activation of Rac1, but sustains the activation of Rap1.
An intracellular pool of LFA-1 (显示 ITGAL 抗体) in naive CD8 (显示 CD8A 抗体)(+) T cells plays a key role in T cell activation and differentiation.
Extracellular ISG15 (显示 ISG15 抗体) signals cytokine secretion through the LFA-1 (显示 ITGAL 抗体) integrin receptor (CD11a (显示 ITGAL 抗体)/CD18) in natural killer cells.
CD18 deficiency curbs methionine-choline-deficient-mediated liver injury by limiting the activation of innate immune cells in the liver without compromising intrahepatic cytokine activation
results identify a role for Caveolin (Cav (显示 CA5A 抗体))1in membrane organization and beta2 integrin Lfa1 (显示 ITGAL 抗体) function in primary CD8 (显示 CD8A 抗体) T cells.
Coro1A (显示 CORO1A 抗体) represents an important novel player in integrin biology, with key functions in polymorphonuclear neutrophils trafficking during innate immunity.
These results identify CD47 (显示 CD47 抗体) as an important regulator of LFA-1 (显示 ITGAL 抗体) and VLA-4 integrin-adhesive functions in T cell proliferation.
Identification of numerous variations in exonic and intronic regions within the ITGB2 gene in Bos taurus and indicus screened for bovine leukocyte adhesion deficiency.
intramammarily administered lipopolysaccharides seem to play an important role in modulating L-selectin (显示 SELL 抗体) and beta2 integrin expression on circulating bovine polymorphonuclear leukocytes
A delay in apoptosis was demonstrated in CD18-deficient bovine neutrophils and this appeared to be closely associated with lowered signalling via [Ca2 (显示 CA2 抗体)+]i, diminished annexin V (显示 ANXA5 抗体) expression on the cell surface, and decreased caspase 3 (显示 CASP3 抗体) activity in lysates
The I-EGF (显示 EGF 抗体)-3 domain of bovine CD18 (amino acid residues 541-581) is critical for conferring species-specific susceptibility to Mannheimia haemolytica leukotoxin.
These results clearly indicate that the bovine CD18 subunit of beta(2)-integrins is the functional receptor for M. haemolytica Lkt.[ruminant-specific leukotoxin]
study provides evidence that the expression of CD18 was downregulated by the plasma glycoforms of alpha-1 acid glycoprotein (显示 ORM1 抗体) and inhibited the chemotaxis of monocytes
Loss of CD18 is associated with bovine leukocyte adhesion deficiency.
Intact signal peptide of CD18, the beta-subunit (显示 POLG 抗体) of beta2-integrins, renders ruminants susceptible to Mannheimia haemolytica leukotoxin.
CR3 (显示 ITGAM 抗体) plays a cardinal (显示 CARD8 抗体) role in beta-glucan signalling in porcine neutrophils, while macrophages use a more diverse receptor array to detect and respond towards beta-glucans.
The expression of zona pellucida glycoprotein 3 (显示 ZP3 抗体) and integrin beta-2 in oocytes after brilliant cresyl blue staining is reported.
early CD18 downregulation is profitable for the host in a situation with an intense LPS (显示 IRF6 抗体) stimulus
It is concluded that porcine CD18 is necessary to mediate A. pleuropneumoniae ApxIIIA toxin-induced leukolysis.
Integrin CD11c (显示 ITGAX 抗体)/CD18 alpha-chain (显示 FCGRT 抗体) phosphorylation is functionally important.
The product of this gene belongs to the integrin beta chain family of proteins. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. This gene encodes the integrin beta chain beta 2. A given chain may combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA-1, and combines with the alpha M chain to form the integrin Mac-1. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Defects in this gene are the cause of leukocyte adhesion deficiency type I (LAD1). Two transcript variants encoding the same protein have been identified for this gene.
cell surface adhesion glycoprotein LFA-1/CR3/P150,959 beta subunit precursor)
, cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta
, complement receptor C3 beta-subunit
, complement receptor C3 subunit beta
, integrin beta chain, beta 2
, integrin beta-2
, leukocyte cell adhesion molecule CD18
, leukocyte-associated antigens CD18/11A, CD18/11B, CD18/11C
, Mac-1 beta
, lymphocyte function associated antigen 1
, macrophage antigen-1 beta
, CD18 subunit
, Leu-CAM receptor
, integrin, beta 2 (antigen CD18 subunit (p95), lymphocyte function-associated antigen 1, integrin B2)
, integrin beta 2 subunit
, CD18 leukocyte adhesion molecule
, antigen CD18
, integrin beta-2 chain
, integrin beta 2
, integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated antigen 1
, integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated antigen 1; macrophage antigen 1 (mac-1) beta subunit)
, macrophage antigen 1 (mac-1) beta subunit)
, Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta
, Complement receptor C3 subunit beta
, Integrin beta-2
, integrin beta-2 subunit
, integrin subunit beta 2 S homeolog
, integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)