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Interferon, lambda 4 (Gene/pseudogene) 抗体

(Interferon, lambda 4 (Gene/pseudogene) (IFNL4))

This gene is a polymorphic pseudogene which, in some humans, encodes the interferon (IFN) lambda 4 protein. Humans are polymorphic for the dinucleotide TT/deltaG allele. Compared to the ancestral state in non-human primates, the TT allele produces a frameshift in the coding region of this gene which is predicted to induce nonsense-mediated mRNA decay. This allele, and an allele in the first intron of this gene, have experienced a rapid increase in frequency and show indications of positive selection. The ancestral states of these alleles are associated with an impaired ability to clear hepatitis C virus. This gene, like other type III interferons (IFNs), interacts with the IFN lambda receptor complex (IFNLR) whose signaling is generally restricted to epithelial cells. This gene resides in a cluster of four type III IFN genes and at least two pseudogenes on chromosome 19q13.2. In general, interferons are produced in response to viral infection and block viral replication and propagation to uninfected cells by activating the JAK-STAT pathway and up-regulating antiviral genes. Multiple alternatively spliced transcripts have been described for this gene but their biological validity and protein coding status is still being ascertained. [provided by RefSeq, May 2017].

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Interferon, lambda 4 (Gene/pseudogene) (IFNL4) (AA 34-76) 抗体 (ABIN7156613)

IFNL4 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated

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IFNL4 适用: 人 ELISA 宿主: 兔 Polyclonal HRP

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IFNL4 适用: 人宿主: 兔 Polyclonal FITC

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Popular Interferon, lambda 4 (Gene/pseudogene) 抗体

Product

Reactivity

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Cat. No.

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Datasheet

anti-Interferon, lambda 4 (Gene/pseudogene) (IFNL4) (AA 34-76) 抗体

Reactivity Human

Application ELISA, IF

Validations

Cat. No. ABIN7156613

Quantity 100 μg

Datasheet Datasheet

anti-Interferon, lambda 4 (Gene/pseudogene) (IFNL4) (AA 34-76) 抗体 (HRP)

Reactivity Human

Application ELISA

Validations

Cat. No. ABIN7156616

Quantity 100 μg

Datasheet Datasheet

anti-Interferon, lambda 4 (Gene/pseudogene) (IFNL4) (AA 34-76) 抗体 (FITC)

Reactivity Human

Application

Validations

Cat. No. ABIN7156615

Quantity 100 μg

Datasheet Datasheet

anti-Interferon, lambda 4 (Gene/pseudogene) (IFNL4) (AA 34-76) 抗体 (Biotin)

Reactivity Human

Application ELISA

Validations

Cat. No. ABIN7156614

Quantity 100 μg

Datasheet Datasheet

anti-Interferon, lambda 4 (Gene/pseudogene) (IFNL4) (AA 34-76) 抗体 (FITC)

Reactivity Human

Application ELISA

Validations

Cat. No. ABIN6083140

Quantity 100 μL

Datasheet Datasheet

Aliases for Interferon, lambda 4 (Gene/pseudogene) 抗体

interferon lambda 4 (gene/pseudogene) (IFNL4) 抗体
IFN-lambda-4 抗体
IFNAN 抗体

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Aliases for Interferon, lambda 4 (Gene/pseudogene) 抗体

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