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megalin (显示 LRP2 蛋白) is critical for mitochondrial biology; mitochondrial intracrine signaling is a continuum of the retrograde early endosome-to-Golgi-Rab32 (显示 RAB32 蛋白) pathway and defects in this pathway may underlie disease processes in many systems.
When compared to the gemcitabine-sensitive cells, the gemcitabine-resistant cells had a higher level of MCF2L expression, suggesting that MCF2L plays an important role in gemcitabine resistance
patients with OCRL-1 (显示 OCRL 蛋白) mutations or type 1 Dent disease showed abnormally low levels of urinary A-megalin (显示 LRP2 蛋白)
An Emerging Role for Megalin (显示 LRP2 蛋白) as a Regulator of Protein Leak in Acute Lung Injury.
Review of LRP2 (显示 LRP2 蛋白) function. LRP2 (显示 LRP2 蛋白) functions are crucial for developmental processes in a number of tissues, including the brain, the eye, and the heart, and defects in this receptor pathway are the cause of devastating congenital diseases in humans.
A novel LRP2 (显示 LRP2 蛋白) missense variant rs17848169 (N2632D) was found to be associated with lower risk for T2D-ESRD in this population.
we discovered one novel locus (LRP2 (显示 LRP2 蛋白); most significant single nucleotide polymorphism rs12988804) that reached genome-wide significance in predicting relapse risk (HR=2.18, p=3.30x10(-8)).
miR (显示 MLXIP 蛋白)-148b directly down-regulates renal megalin (显示 LRP2 蛋白) expression.
Exocytosis-mediated urinary C-megalin (显示 LRP2 蛋白) excretion is associated with the development and progression of diabetic nephropathy in T2DM, particularly due to megalin (显示 LRP2 蛋白)-mediated lysosomal dysfunction in proximal tubules.
The studies suggest that impaired endocytosis of megalin (显示 LRP2 蛋白)/cubilin (显示 CUBN 蛋白) ligands, hemoglobin (显示 HBB 蛋白) and albumin (显示 ALB 蛋白), rather than heme toxicity, may be the cause of tubular proteinuria in sickle cell disease patients.
the PH domain of Dbs has a role in regulating Rho GTPase (显示 RACGAP1 蛋白) activation
the PH domain of Dbs has two roles in the regulation of DH domain function, one for GTPase (显示 RACGAP1 蛋白) association and activation in vitro and one for phosphoinositide binding and GTPase (显示 RACGAP1 蛋白) interaction in vivo, that together promote Dbs association with membranes.
Dbs is activated by Rac1 at the pleckstrin (显示 PLEK 蛋白) homology domain
Dbs has the potential to promote proliferation of immature thymocytes, but also sensitizes immature thymocytes to deletion.
Crystal structure of the DH/PH fragment of Dbs without bound GTPase (显示 RACGAP1 蛋白)
the Sec14 domain regulates Dbs transformation through at least two distinct mechanisms, neither of which appears to directly influence the in vivo exchange activity of the protein
Dbs transformation is associated with increased phosphorylation of myosin light chain and stress fiber formation, both of which occur in a ROCK-dependent manner
The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. This protein also has a role in cell-signaling\; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in this gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR).
DBL's big sister
, MCF2 transforming sequence-like protein
, guanine nucleotide exchange factor DBS
, MCF2-transforming sequence-like protein
, OST oncogene
, mcf.2 transforming sequence-like
, MCF.2 cell line derived transforming sequence-like
, coagulation factor VII
, guanine nucleotide exchange factor DBS-like
, Ost gamma
, exchange factor for RhoA and Cdc42
, guanine nucleotide exchange factor OSTIII